DOTAZOLand NODAGAZOL for theranostics of bone metastases

Conclusion: The Ga-68-labeled NODAGA based zoledronic acid derivative NODAGAZOL shows quantitative labeling and does not require subsequent purification. Both Ga-68-NODAGAZOL and Ga-68-DOTAZOL exhibit high bone accumulation, low uptake in soft tissue and fast renal clearance. Bone accumulation was higher for NODAGAZOL compared to DOTAZOL, which matches the experimental data obtained earlier for Ga-68-NO2APBP vs. Ga-68-BPAMD. Considering the potential of DOTAZOL for endoradiotherapy with Lu-177, Ga-68-NODAGAZOL appears to become the diagnostic arm for the theranostic pair for bone metastases. Research Support:
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Radiotherapy and Monitoring Therapy Source Type: research