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'All Scientific Hands On Deck' To End The Opioid Crisis

By Nora Volkow (Director, NIDA) and Francis Collins (Director, NIH) In 2015, 2 million people had a prescription opioid use disorder and 591,000 suffered from a heroin use disorder; prescription drug misuse alone cost the nation $78.5 billion in health care, law enforcement, and lost productivity. But while the scope of the crisis is staggering, it is not hopeless. We understand opioid addiction better than many other drug use disorders; there are effective strategies that can be implemented right now to save lives and to prevent and treat opioid addiction. At the National Rx Drug Abuse and Heroin Summit in Atlanta, GA last month, lawmakers and representatives from healthcare, law enforcement, and many private stakeholders from across the nation affirmed a strong commitment to end the crisis. Research will be a critical component of achieving this goal. Today in the New England Journal of Medicine, we laid out a plan to accelerate research in three crucial areas: overdose reversal, addiction treatment, and pain management. First, there is a need to develop additional overdose-reversal interventions and improved formulations of naloxone to reduce mortality. Naloxone is very effective at reversing overdoses, but bystanders may not reach the person in time and the usual doses given may not be powerful or long-lasting enough to reverse overdoses on fentanyl and other highly potent synthetic opioids. In addition to new or differently formulated antagonists of the mu-opioid r...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Discussion: All comparisons between scale scores and PSG results showed poor or totally absent concordance between subjective and objective measures.Significance: The subjective evaluation of sleep in HD patients shows a poor correlation with PSG results.Neurodegener Dis 2017;17:330-337
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research
International Szent-Györgyi Prize for Progress in Cancer Research: basic and translational research recognition : Mary-Claire King received the 2016 Prize for her pioneering research that demonstrated the first evidence of genetic predisposition to breast cancer. Chin J Cancer. 2017 Nov 21;36(1):92 Authors: Hartmann H, Zhao J, Ba S Abstract The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award sponsored by the National Foundation for Cancer Research (NFCR)-a leading cancer research charitable organization in the United States that supports innovative cancer...
Source: Chinese Journal of Cancer - Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
This article on SAD describes it as follows: Seasonal affective disorder is characterized by feelings of sadness and depression that occur in the fall or winter months when the temperatures begin to drop and the days grow shorter. The depressive episode is often associated with excessive eating, sleeping, and weight gain. Depressive symptoms begin in the fall or winter and persist until the spring. Women are twice to three times more likely to suffer from the winter blues than men. Seasonal affective disorder can also impact people during the summer months (“the summer blues”), too, but it is less common. Peopl...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression OCD Research Obsessive Compulsive Disorder Sad Seasonal Affective Disorder Source Type: blogs
CONCLUSIONS: Targeted therapies, lenvatinib and dabrafenib plus trametinib (for BRAF V600E mutants), may provide clinical benefit in ATC patients who are unable to participate in clinical trials, with manageable toxicities. PMID: 29161986 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
CONCLUSIONS: With appropriately scaled protocols of sedatives and analgesics administration, intensive care nurses may easily target the consistent and optimal assessment and provide pain relief prior to sedation, which will improve the quality of sedation and patient safety. PMID: 29164549 [PubMed - in process]
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Hu Li Za Zhi Source Type: research
In a ground-breaking study featuring over 100,000 women, scientists have determined that smoking increases the risk of developing breast cancer by up to 35%.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Authors: Fontoura JL, Baptista C, Pedroso FB, Pochapski JA, Miyoshi E, Ferro MM Abstract Besides being better known for causing motor impairments, Parkinson's disease (PD) can also cause many nonmotor symptoms, like depression and anxiety, which can cause significant loss of life quality and may not respond to regular drugs treatment. In this review, we discuss the depression in PD, based on data from studies in humans and rodents. Depression frequency seems higher in PD patients than in general population, despite high variation in data due to diagnosis disparities. Development of depression in PD seems more likel...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Authors: Dogan M, Algin E, Guven ZT, Baykara M, Kos TF, Bal O, Zengin N Abstract INTRODUCTION: We aimed to evaluate the prognostic significance of neutrophil-lypmhocyte ratio (NLR), platelet-lymphocyte ratio (PLR), neutrophil-platelet score (NPS) and prognostic nutritional index (PNI) as proinflammatory markers in metastatic pancreas cancer (MPC). MATERIAL AND METHODS: 146 MPC patients followed-up at our center were evaluated retrospectively for clinicopathological characteristics and hematological ratios (NLR, PLR, NPS and PNI). PNI was calculated as [10 x serum albumin (g/dL)] + [0.005 x peripheral lymphocyte...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Authors: Pollano A, Trujillo V, Suárez MM Abstract Vulnerability to emotional disorders like depression derives from interactions between early and late environments, including stressful conditions. The serotonin (5HT) system is strongly affected by stress and chronic unpredictable stress can alter the 5HT system. We evaluated the distribution of active serotonergic neurons in the dorsal raphe nucleus (DR) through immunohistochemistry in maternally separated and chronically stressed rats treated with an antidepressant, tianeptine, whose mechanism of action is still under review. Male Wistar rats were subject...
Source: Stress - Category: Research Tags: Stress Source Type: research
Authors: Cadalso RT, Daugherty J, Holmes C, Ram S, Enciso R Abstract AIMS: To determine the efficacy of occipital nerve stimulation (ONS) in reducing the intensity, duration, and frequency of medically intractable primary headaches. METHODS: A systematic review was carried out by searching three electronic databases: the Cochrane Library, MEDLINE via PubMed, and Web of Science. Randomized controlled trials (RCTs) and case series were eligible for inclusion. RCTs were assessed for quality of evidence by using the Cochrane Risk of Bias and the Grading of Recommendations Assessment, Development, and Evaluation (GR...
Source: Journal of Orofacial Pain - Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research
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