Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population

Conclusions: Using the CC mouse population model, we have demonstrated a complex and highly variable relationship between PERC and TCA toxicokinetics and toxicodynamics at the population level. https://doi.org/10.1289/EHP788 Received: 11 July 2016 Revised: 26 September 2016 Accepted: 25 October 2016 Published: 30 May 2017 Address correspondence to I. Rusyn, TAMU, Texas A&M University, College Station, TX 77843, USA. Telephone: (979) 458-9866. E-mail: irusyn@cvm.tamu.edu Supplemental Material is available online (https://doi.org/10.1289/EHP788). The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Supplemental Material PDF (216 KB) Note to readers with disabilities: EHP has provided a 508-conformant table of contents summarizing the Supplemental Material for this article (see below) so readers with disabilities may determine whether they wish to access the full, nonconformant Supplemental Material. If you need assistance accessing jou...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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Publication date: February 2020Source: Alter, Volume 14, Issue 1Author(s):
Source: ALTER - European Journal of Disability Research - Category: Disability Source Type: research
In this study we tried to explore Diazepam as a repurposed drug and tested it in Neuroblastoma (Neuro 2a) cells. Diazepam loaded Poly Lactic Acid Nanoparticles were developed (D-PLA-NPs) using nanoprecipitation method. Entrapment efficiency was found to be ± 99.7% and drug loading was ± 12.88%. The particle size developed was 188.8 nm and zeta potential was −25.6 millivolt. Dissolution profiles were studied in PBS (pH 7.4) or simulated media, almost 50% release was observed within 6 h. In vitro, cytotoxicity was analyzed using MTT assay where dose-dependent cytotoxicity was observed for developed D-PLA-NPs.
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 22 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Brian W. Bauer, Anna R. Gai, Mary E. Duffy, Megan L. Rogers, Lauren R. Khazem, Rachel L. Martin, Thomas E. Joiner, Daniel W. CapronAbstractModern theories of suicide, such as the Interpersonal Theory of Suicide, have overcome past conceptual limitations within suicide research by examining factors that help differentiate suicide attempters from those who experience suicidal ideation, but never attempt suicide. One such factor that has been studied extensively is fearlessness about death. Given the varying levels of lethalit...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Abstract Two novel electrochemiluminescence (ECL) deoxyribosensors are designed for assay of early lung cancer biomarker (NAP2) using the DNA three-way junction (DNA-TWJ) inserted NAP2 binding aptamer between two double-helical stems and labeled with ruthenium (II) complex (Ru) (NBAT-Ru) taken as molecular recognition element. The signal-off ECL deoxyribosensor was fabricated by covalently coupling the 5'-NH2-(CH2)6-NBAT-Ru to glassy carbon electrode surface modified with 4-aminobenzoic acid (4-ABA). After combining NAP2 and NBAT-Ru, the changed conformation of NBAT-Ru altered the distance between Ru complex and e...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Abstract The expression level of miRNA-21 is closely related to the occurrence and development of cancer, especially in gastrointestinal cancer. Monitoring miRNA-21 has clinical application in the diagnosis and evaluation of gastrointestinal cancer. A turn-on ratiometric fluorescence bioassay based on the T7 exonuclease-mediated cyclic enzymatic amplification method was developed for miRNA-21 determination by using carbon dots (CDs) and FAM-labeled ssDNA as the signal source. CDs demonstrated the triple functions of built-in internal fluorescence, probe carrier, and quencher in this strategy. In the absence of miR...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Abstract Development of a mitochondria-targeting fluorescent probe with large Stokes shift and long-wavelength emission was benefit for accurate detection of hypoxic status, which was known as a major factor of the tumor physiology and influence important pathological processes. However, an efficient optical approach for simultaneously achieving such merits was still lacking. In this work, a turn-on fluorescence probe (HBT-NP) was designed to assess the hypoxic condition of tumor cells by detecting nitroreductase (NTR). Probe HBT-NP was constructed by conjugating 4-nitrobenzyl moiety as reaction site for NTR to 2-...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
This study provides a powerful approach for detection of highly reactive and unstable H2S biomolecules in live systems. PMID: 32081180 [PubMed - in process]
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Publication date: July 2020Source: Radiation Physics and Chemistry, Volume 172Author(s): A.S. Mustaqim, N.Z. Yahaya, N.N.A. Razak, H. ZinAbstractThe cancer treatment modalities have been developed rapidly with the aim to maximize the absorbed dose toward the cancer cells while sparing the healthy tissues. The use of high atomic number, Z nanomaterials has become interest as it offers the possibilities such as destroying cancer tumor with minimal damage to the healthy tissues. The study aimed to evaluate the role of methylene blue as it reduced the self-polymerization as well as to measure the dose enhancement effect of Zin...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners. Click arrow to […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology ACE2 China coronavirus CoV COVID-19 epidemic evolution furin pangolin pneumonia receptor binding domain respiratory aerosol SARS-CoV-2 spike glycoprotein viral viruses Wuhan zoonosis Source Type: blogs
CONCLUSION: Repeat transoral laser microsurgery can be an oncologically safe alternative to other salvage therapies for glottic squamous cell carcinoma recurrence, without sacrificing functional outcomes. PMID: 32079549 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
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