Introduction

Stereotactic body radiotherapy (SBRT), also referred to as stereotactic ablative radiotherapy (SABR), is increasingly been used by radiation oncologists to treat a variety of tumors including most commonly those located in the lung, spine, liver, and pancreas. The principles of SBRT or SABR, including the use of hypofractionation and high-dose per fraction to achieve sharp dose gradients, can result in greater tumor control and better integration with other cancer therapies. However, this technology must be applied judiciously as the risk of harming patients is also increased.
Source: Seminars in Radiation Oncology - Category: Cancer & Oncology Authors: Source Type: research

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Conclusions: Our results describe novel antisense lncRNAs associated with HMGA1 and HMGA2 genes. In particular, we demonstrate that HMGA2-AS1 is involved in the regulation of its own sense gene expression, mediating tumorigenesis. Thus, we highlight a new layer of complexity in the regulation of HMGA2 expression, providing new potential targets for cancer therapy.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionThe available evidence suggests that volume of systemic therapy provision for solid tumors may be associated with improved survival. However, each study identified in this review contains such considerable methodologic shortcomings and/or unresolved confounding that estimation of an unbiased treatment effect is not possible. High quality research is needed prior to implementation of volume-based regionalization policies for systemic therapy.
Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: Our findings suggest that PAM can induce apoptosis of Aspc1 cells through ROS-dependent autophagy and may be a candidate for use in pancreatic cancer therapeutics.
Source: In Vivo - Category: Research Authors: Tags: Experimental Studies Source Type: research
First Orphan Drug Designation for OBI-999, a novel first-in-class Antibody-Drug Conjugate targeting Globo H, a glycolipid antigen found on multiple tumor types TAIPEI, Taiwan, Dec. 26, 2019 -- (Healthcare Sales &Marketing Network) -- OBI Pharma, Inc.,... Biopharmaceuticals, Oncology, FDA OBI Pharma, Globo H, Pancreatic Cancer
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
AbstractVessel co-option is a non-angiogenic mechanism of tumour vascularisation in which cancer cells utilise pre-existing blood vessels instead of inducing new blood vessel formation. Vessel co-option has been observed across a range of different tumour types, in both primary cancers and metastatic disease. Importantly, vessel co-option is now implicated as a major mechanism that mediates resistance to conventional anti-angiogenic drugs and this may help to explain the limited efficacy of this therapeutic approach in certain clinical settings. This includes the use of anti-angiogenic drugs to treat advanced-stage/metasta...
Source: Angiogenesis - Category: Molecular Biology Source Type: research
Miller Biswas Acharyya Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer type in which the mortality rate approaches the incidence rate. More than 85% of PDAC patients experience a profound loss of muscle mass and function, known as cachexia. PDAC patients with this condition suffer from decreased tolerance to anti-cancer therapies and often succumb to premature death due to respiratory and cardiac muscle wasting. Yet, there are no approved therapies available to alleviate cachexia. We previously found that upregulation of the metal ion transporter, Zip14, and altered zinc homeostasis are critical me...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 12 December 2019Source: Chemico-Biological InteractionsAuthor(s): Chao Zhao, Dun Wang, Zexuan Gao, Hongfeng Kan, Feng Qiu, Lixia Chen, Hua LiAbstractProtein kinases play an indispensable role in signaling pathways that regulate tumor cell functions, which represent potent therapeutic targets in cancers. Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) as a serine/threonine kinase has recently been reported to be upregulated in pancreatic ductal adenocarcinoma (PDAC) and show protumorigenic effect. By activity-guided phytochemical investigation of the extracts from Gl...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Abstract Protein kinases play an indispensable role in signaling pathways that regulate tumor cell functions, which represent potent therapeutic targets in cancers. Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) as a serine/threonine kinase has recently been reported to be upregulated in pancreatic ductal adenocarcinoma (PDAC) and show protumorigenic effect. By activity-guided phytochemical investigation of the extracts from Glycyrrhiza uralensis Fisch, we expect to find the effective constituents that can suppress pancreatic cancer cell proliferation and/or induce cells apoptotic by inhibi...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
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