The impact of white matter lesions on the cognitive outcome of subthalamic nucleus deep brain stimulation in Parkinson ’s disease

Cognitive decline is a common symptom of Parkinson ’s disease (PD). Mild Cognitive Impairment (MCI) affects about a third of PD patients within the first five years after diagnosis [1]. In the Movement Society Task Force Criteria, PD-MCI is defined as a cognitive decline in the context of PD which is not sufficient to interfere with functional ind ependence [2]. Pure frontal deficits in executive functions may not be generally associated with a higher risk for dementia [3]. Instead, reduced semantic fluency and narrowed visual-constructive functioning indicate the progression from MCI to dementia in PD (PD-D) [4].

Source: Clinical Neurology and Neurosurgery - May 31, 2017 Category: Neurosurgery Authors: J. Blume, M. Lange, E. Rothenfusser, C. Doenitz, U. Bogdahn, A. Brawanski, J. Schlaier Source Type: research