Successful resolution of Epstein –Barr virus-associated hemophagocytic lymphohistiocytosis during the treatment course of acute lymphoblastic leukemia

A primary infection of Epstein –Barr virus (EBV) in naïve B-cells is mostly asymptomatic, but occasionally causes infectious mononucleosis (IM). In contrast, the ectopic EBV infection in T-cells causes “systemic EBV-positive T-cell lymphoproliferative diseases (LPD) in childhood” including EBV-associated hemophagocytic lym phohistiocytosis (EBV-HLH) and a chronic active EBV infection.1 EBV-HLH rarely occurs in children during the treatment course of acute lymphoblastic leukemia (ALL). We hereby report a pediatric case of primary EBV infection-associated HLH during the induction treatment of precursor B-cell ALL.

Source: Pediatrics and Neonatology - May 31, 2017 Category: Perinatology & Neonatology Authors: Mari Harada, Yuko Honda, Takayuki Hoshina, Shouichi Ohga, Koichi Ohshima, Koichi Kusuhara Tags: Brief Communication Source Type: research