Smad7 protects against Acute Kidney Injury by rescuing tubular epithelial cells from the G1 cell cycle arrest

In conclusion, Smad7 plays a protective role in AKI. Blockade of TGF-β/Smad3-p21/p27-induced G1 cell cycle arrest may be a key mechanism by which Smad7 treatment inhibits AKI. Thus, Smad7 may be a novel therapeutic agent for AKI.

Source: Clinical Science - May 31, 2017 Category: Biomedical Science Authors: Fu, S., Tang, Y., Huang, X. R., Feng, M., Xu, A., Lan, H. Y. Tags: PublishAheadOfPrint Source Type: research