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When DAA Treatment for Hepatitis C Fails, 3-Drug Regimen " Highly Effective " (FREE)

By Kelly Young Edited by Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, DFASAM The combination of sofosbuvir, velpatasvir, and voxilaprevir is effective for hepatitis C in patients with virologic failure after direct-acting antiviral agent (DAA) treatment, according to two phase 3, industry-funded trials in the …
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news

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The finding by Remmler et  al1 that increased levels of interleukin 6 (IL6) predict 90-day and 1-year mortality in patients with end-stage liver disease is of high importance. In addition to its relevance for prognosis and timing of liver transplantation, we believe that the determination of IL6 levels could represent a pos sible target for therapy. Indeed, IL6 increases occur in autoimmune diseases, but more importantly is a consequence of infections. Viral causes of chronic liver diseases, such as hepatitis C and B viruses, now can be cured in a very high percentage of patients with the administration of antivirals.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
ann Gisa Gerold Hepatitis C virus (HCV) enters human hepatocytes using four essential entry factors, one of which is human CD81 (hCD81). The tetraspanin hCD81 contains a large extracellular loop (LEL), which interacts with the E2 glycoprotein of HCV. The role of the non-LEL regions of hCD81 (intracellular tails, four transmembrane domains, small extracellular loop and intracellular loop) is poorly understood. Here, we studied the contribution of these domains to HCV susceptibility of hepatoma cells by generating chimeras of related tetraspanins with the hCD81 LEL. Our results show that non-LEL regions in addition to ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
This study contributes to the understanding of host miRNA participation in antiviral processes of IFN.
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Microbiology Source Type: research
Publication date: 2018 Source:Materials Today: Proceedings, Volume 5, Issue 3, Part 1 Author(s): Gargi Tiwari, Vishnudatt Pandey, Rajendra Prasad Ojha Hepatitis C Virus (HCV) NS5B protein is a RNA-dependent RNA polymerase essential for replication of the viral RNA genome. Genome of HCV is an RNA molecule of approximately 9600 nucleotides, structured in a coding region that contains one large open reading frame (ORF), flanked by non-translated regions (NTR) at the 5’ and 3’ ends encoding a polyprotein precursor of about 3,000 amino acids. High concentrations of GTP (guanosine 5’-triphosphate) have been sh...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Conclusion: Retreatment with the 12-week combination regimen of grazoprevir and elbasvir is effective for HCV GT1b patients who discontinue the HCV NS5A inhibitor-including regimens within 2 weeks. The treatment response may be related to the short duration of initial treatment, which did not produce treatment-emergent RASs. PMID: 29662642 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In 2016, all 50 states and the District of Columbia submitted reports of acute hepatitis A virus (HAV) infection, 48 states submitted reports of acute hepatitis B virus (HBV) infection, 42 submitted reports of acute hepatitis C virus (HCV) infection, 43 submitted reports of chronic HBV infection, and 42 submitted reports of chronic HCV infection.
Source: PHPartners.org - Category: International Medicine & Public Health Source Type: news
Last year, a record number of new treatments and cures that are transforming care for patients fighting debilitating diseases like cancer, hepatitis C, high cholesterol and more were approved by the U.S. Food and Drug Administration. In the midst of all this incredible progress, spending on medicines grewjust 0.6 percent in 2017, according to the newIQVIA Institute for Human Data Science “2017 Medicine Use and Spending in the U.S.” report.
Source: The Catalyst - Category: Pharmaceuticals Tags: FDA cancer drug cost Hepatitis C high cholesterol Biologics and Biosimilars Source Type: news
CONCLUSIONS: An expanded CLD definition and alcohol-attributable fractions can be used to create comprehensive data on CLD mortality. When stratified by CLD cause and demographic characteristics, these data may help states and jurisdictions improve CLD prevention programs. PMID: 29664698 [PubMed - as supplied by publisher]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
It is well recognized that the shortage of available kidneys has resulted in long wait times for dialysis patients seeking transplantation and that many patients die before receiving an allograft. Yet, the data presented by Reese et  al.,1 in their early, thoughtful proposal to begin considering transplanting hepatitis C virus (HCV)–positive kidneys, reveal that in the United States between 2005 and 2014, 4144 kidneys from 3273 deceased donors with hepatitis C antibody were discarded. With the recent development of highly ef fective, well-tolerated oral agents to treat HCV infection, it would seem desirable to t...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
Conclusions: Surgical resection might be an effective treatment in HCC patients with PVI. PMID: 29665630 [PubMed - as supplied by publisher]
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
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