When DAA Treatment for Hepatitis C Fails, 3-Drug Regimen " Highly Effective " (FREE)
By Kelly Young Edited by Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, DFASAM The combination of sofosbuvir, velpatasvir, and voxilaprevir is effective for hepatitis C in patients with virologic failure after direct-acting antiviral agent (DAA) treatment, according to two phase 3, industry-funded trials in the …
Merck&Co on Thursday announced price cuts to some of its medicines, including a 60 percent reduction to a little-used hepatitis C treatment, after U.S. President Donald Trump criticized drugmakers for failing to help reduce healthcare costs for consumers.
ANN ARBOR, Mich. (CBS Local) – A disturbing new study declares that a growing number of young Americans are drinking themselves to death. The findings point to a skyrocketing increase in cirrhosis and liver cancer deaths over the last decade. According to the report published in the journal BMJ, deaths due to cirrhosis increased by 65 percent from 2009 to 2016. Deaths from liver cancer doubled (from more than 5,100 to nearly 11,100) during the same time period. Americans between 25-34 were found to be the largest group affected. Cirrhosis is a disease commonly caused by excessive drinking or ...
Sample: Which type of practitioner most often make the diagnosis of HCV: Gastro? GP? Hepatologist? Other?
ConclusionsThis systematic review confirms that new DAAs are more effective in inducing SVR than placebo. Outside clinical trials, in real word HCV cure with DAA regimens occurs in less than 90% of patients, so further comparative evaluations are needed to establish their long-term effects.
Condition: Hepatitis c Intervention: Sponsor: Assiut University Not yet recruiting
Authors: Tachi K PMID: 30013253 [PubMed - in process]
This study evaluated the analytical performance of HCV core antigen (HCVcAg) detection in samples of plasma and dried venous blood spots (DBSs). Paired plasma and DBS samples were prepared from remnant diagnostic samples. Plasma HCV RNA was quantified and measured. Sensitivity and specificity for HCVcAg (>3 fmol/L) at two HCV RNA thresholds (≥15 and ≥3000 IU/mL) were calculated. Of 120 paired samples tested, 25 had nonquantifiable HCV RNA and 95 had quantifiable HCV RNA. The median HCV RNA level in plasma was 5.6 log10 IU/mL (interquartile range: 5.2 to 6.2). The median HCVcAg levels in plasma and DBS samples were...
Conclusions: Though the number of patients examined was limited, NS3 variants with RASs appear to be major components of both intrahepatic and circulating viral quasispecies populations in DAA-na ïve patients.Intervirology
CONCLUSIONS: This study found a significant association between HBV and integrin α6, which may be responsible for early migration and invasion of HCC. Thus, integrin α6 is a predictive marker for tumor recurrence and invasiveness of HBV-driven HCC. PMID: 30010110 [PubMed - as supplied by publisher]
Conclusion: Given the relationship between the baseline HCC-specific immune surveilling T cell responses and therapy-associated HCC emergence, and the impact of HCV clearance on its strength and magnitude, we recommend a continued HCC screening in cirrhotic HCV patients despite HCV resolution.Liver Cancer