Cancer therapy shows promise for psoriasis treatment

(Medical College of Georgia at Augusta University) HDAC inhibitors, already widely used to treat cancer, may be an effective therapy for psoriasis as well, scientists report.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

Related Links:

Authors: Yao Y, Jørgensen AR, Thomsen SF Abstract The introduction and continuous development in biological drugs has greatly improved the therapeutic quality for patients with chronic inflammatory skin conditions. Current approaches to the biologic treatment of psoriasis, atopic dermatitis, chronic spontaneous urticaria, and hidradenitis suppurativa include licensed use of traditional anti-tumor necrosis factor agents, selective interleukin antagonists (IL-4, IL-12/23, IL-17), and the IgE inhibitor omalizumab, and as the knowledge on the pathogenesis of these diseases expands, off-label uses of the currentl...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Walking into the skin care aisle at the pharmacy, stepping up to a counter at a department store, or stopping by a cosmetics shop can be an overwhelming experience. Everywhere you look, you see products touting the ideal skin care ingredient. Who knew buying a moisturizer could be so difficult? Lately, the coverage of “clean” cosmetics is everywhere — on national television and in best-selling books. It’s clear that clean is the newest beauty trend. But what is the clean cosmetics movement, and does the science support it? Regulatory oversight of cosmetics: A brief history The clean cosmetics moveme...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Health Skin and Hair Care Source Type: blogs
Grains can play havoc with your skin. The prolamin proteins, such as gliadin,  trigger autoimmune skin reactions and turn antibodies against the skin enzymes, their lectins fan the fires of inflammation, their proteins provoke allergies, and their amylopectins send blood sugar and insulin sky-high and provoke the skin-disrupting hormone insulin-like growth factor-1 (IGF). The whole grain package adds up to an impressive collection of skin conditions that can take a variety of forms, from simple red, itchy rashes to scaly, oily raised patches to large vesicles to gangrene. B...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Source Type: blogs
Grains can play havoc with your skin. The prolamin proteins, such as gliadin,  trigger autoimmune skin reactions and turn antibodies against the skin enzymes, their lectins fan the fires of inflammation, their proteins provoke allergies, and their amylopectins send blood sugar and insulin sky-high and provoke the skin-disrupting hormone insulin-like growth factor-1 (IGF). The whole grain package adds up to an impressive collection of skin conditions that can take a variety of forms, from simple red, itchy rashes to scaly, oily raised patches to large vesicles to gangrene. B...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Source Type: blogs
The FDS has warned pharmaceutical companies in the past about their use of paid surrogates on social media sites like Instagram to promote their products (see:Pharmaceutical Companies Continue to Experiment with Social Media;FDA Issues Warning Letter to Drug Company about Use of Instagram;GlaxoSmithKline Mines Social Media for Information about Adverse Drug Events). This issue has recently returned to the news (see:The latest Instagram influencer frontier? Medical promotions. Big pharma is partnering with influencers to sell new drugs and medical devices). Below is an excerpt from the article. It's long and provides ma...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Source Type: blogs
Abstract Water-soluble polymer-methotrexate (MTX) conjugates were obtained via efficient carbodiimide-mediated amidation (E = 17-100%). Binding abilities between water-soluble V-shaped or star-shaped copolymers and MTX were studied by isothermal titration calorimetry spectroscopic (UV-vis, NMR) and microscopic (scanning electron microscopy and transmission electron microscopy) techniques. The efficiency of the amidation reaction has depended on the amount of pendant amino alcohol groups and zeta potential (ZP) values of polymeric carries. The sizes of aggregates formed by polymer-drug conjugates in w...
Source: Biomed Res - Category: Research Authors: Tags: J Biomed Mater Res B Appl Biomater Source Type: research
AbstractWater ‐soluble polymer–methotrexate (MTX) conjugates were obtained via efficient carbodiimide‐mediated amidation (E = 17–100%). Binding abilities between water‐soluble V‐shaped or star‐shaped copolymers and MTX were studied by isothermal titration calorimetry spectroscopic (UV–vis, NMR) and microscopic (scanning electron microscopy and transmission electron microscopy) techniques. The efficiency of the amidation reaction has depended on the amount of pendant amino alcohol groups and zeta potential (ZP) values of polymeric carries. The sizes of aggregates formed by polymer&n...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - Category: Materials Science Authors: Tags: Original Research Report Source Type: research
The use of immune checkpoint inhibitors (ICIs) has hugely incremented as it has become the standard therapy for a wide range of cancer types. Such monoclonal antibodies act against inhibitory immune receptors cytotoxic T-lymphocyte antigen 4 (CTLA-4) (ipilimumab and tremelimumab) and programmed cell death 1 (PD-1) (nivolumab and pembrolizumab) by boosting the immune response of T cells [1]. Despite favourable oncological outcomes, these treatments have also been associated with a unique spectrum of side-effects known as immune-related adverse events (irAEs) [2].
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Letter to the Editor Source Type: research
Authors: Rahkola D, Laitala J, Siiskonen H, Pelkonen J, Harvima IT Abstract By using immunohistochemistry and antibodies that identify complement C3c (in C3 and C3b) or CD11b receptor, we report that the proportion C3c+ mast cells and the number of CD11b+ cells are increased in basal cell carcinoma (BCC). Instead, only CD11b+ cells are increased in squamous cell carcinoma/Bowen's disease, and only slightly so in actinic keratosis. Only C3c+ mast cells are increased in psoriasis. Furthermore, C3c+ mast cells correlated positively with CD11b+ cells, and iC3b immunoreactivity was detected around tryptase+ mast cells. ...
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
In this study, the efficacy of clarithromycin in protecting against pulmonary fibrosis was investigated in the rat model for methotrexate-induced pulmonary fibrosis. Material and methods: A total of 30 female rats were divided into three groups. Group I was administered intraperitoneal and intragastric saline; group II was administered oral 3 mg/kg methotrexate; and group III was administered oral 3 mg/kg methotrexate + intraperitoneal 200 mg/kg clarithromycin for 28 days. Histopathological analyses of the lung tissues were performed under light microscopy. Results: Normal histopathological changes were observed in t...
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
More News: Biology | Cancer | Cancer & Oncology | Cancer Therapy | Psoriasis