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Mithra receives approval in France to market hormone replacement therapy Tibelia

Women's health specialist Mithra has received a marketing authorisation (MA) for the commercialisation of Tibelia in France.
Source: Pharmaceutical Technology - Category: Pharmaceuticals Source Type: news

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ConclusionsWe confirm in this Mediterranean population the association of increasing MBD, classified according to BI-RADS with BC risk also taking into account other well-known risk factors for this neoplasm.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
This study evaluated the association of primary open angle glaucoma with smoking, health and ocular factors among Chinese Singaporeans. DesignCase‐control study Participants711 primary open angle glaucoma patients from a Singapore hospital and 2788 population‐based controls. MethodsSubjects underwent clinical examination and completed a questionnaire with details on family history of glaucoma, comorbidities, smoking, alcohol consumption, age at menopause and use of hormone replacement therapy. Primary open angle glaucoma was sub‐classified as normal‐tension glaucoma and high‐tension glaucoma depending on the untr...
Source: Clinical and Experimental Ophthalmology - Category: Opthalmology Authors: Tags: Original Article Source Type: research
In conclusion, the average effect of HRT use seems not harmful to breast cancer survival. Nevertheless, this effect of HRT use is needed for further assessment. PMID: 28601917 [PubMed - as supplied by publisher]
Source: Breast Cancer - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research
Authors: Engin A Abstract Several studies show that a significantly stronger association is obvious between increased body mass index (BMI) and higher breast cancer incidence. Furthermore, obese women are at higher risk of all-cause and breast cancer specific mortality when compared to non-obese women with breast cancer. In this context, increased levels of estrogens due to excessive aromatization activity of the adipose tissue, overexpression of pro-inflammatory cytokines, insulin resistance, hyperactivation of insulin-like growth factors (IGFs) pathways, adipocyte-derived adipokines, hypercholesterolemia and exce...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
The endometrium exhibits a unique physiology in its ability to cyclically respond to steroid hormones, resulting in morphologic changes that allow the pathologist's interpretation of proper endometrial function. Distinctive changes are also observed during times of physiologic hormonal changes, such as in pregnancy, or in pathologic and iatrogenic hormonal imbalances, as in certain functioning ovarian tumours and hormone therapy, respectively. The ubiquity of these states, in particular the widespread use of oral contraception, hormone replacement therapy, hormonal intrauterine devices, and nowadays frequent use of progest...
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Gynaecological pathology Source Type: research
Xanthomatous hypophysitis (XH) is extremely rare. Only 27 cases have been reported in the literature. No XH patient presenting with diabetes insipidus (DI) has been completely cured through surgery. Here, we describe the first XH case of a DI patient whose pituitary function was normalized postoperatively, without hormone replacement therapy.
Source: World Neurosurgery - Category: Neurosurgery Authors: Tags: Case Report Source Type: research
In conclusion, MTTS is a safe and effective surgical option for pediatric pituitary adenomas with minimal morbidity and excellent outcomes.
Source: Journal of Craniofacial Surgery - Category: Surgery Tags: Clinical Studies Source Type: research
Publication date: Available online 30 May 2017 Source:The Lancet Author(s): Diala El-Maouche, Wiebke Arlt, Deborah P Merke Congenital adrenal hyperplasia is a group of autosomal recessive disorders encompassing enzyme deficiencies in the adrenal steroidogenesis pathway that lead to impaired cortisol biosynthesis. Depending on the type and severity of steroid block, patients can have various alterations in glucocorticoid, mineralocorticoid, and sex steroid production that require hormone replacement therapy. Presentations vary from neonatal salt wasting and atypical genitalia, to adult presentation of hirsutism and irregul...
Source: The Lancet - Category: General Medicine Source Type: research
Authors: Fan J, Zhong Y, Chen C Abstract Our purpose is to explore whether anti-dsDNA antibody, which was demonstrated to enter living cells and induced apoptosis, could adversely affect reproductive outcomes. A total of 259 women receiving the in vitro fertilization-embryo transfer (IVF) cycle were enrolled in this study, including 52 women with positive ANA and anti-dsDNA (ANA+/anti-dsDNA+ group), 86 women with positive ANA and negative anti-dsDNA (ANA+/anti-dsDNA- group), and 121 women with negative ANA and anti-dsDNA (ANA-/anti-dsDNA- group). 136 nonpregnant women among 259 patients in the IVF-ET cycle were enr...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Authors: Beck KL, Anderson MC, Kirk JK Abstract Views and clinical practice on hormone replacement therapy (HRT) for postmenopausal women have varied widely over the last several decades. The 1990s showed a dramatic decline in prescribing and only recently are prescription rates increasing again. Use of HRT is first line for women suffering from the symptoms of menopause. For a certain population of postmenopausal women, HRT is recommended for prevention of fracture. More consideration is being given to patient risk factors, side effects, and formulations available. Transdermal patch estrogen formulations have been...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
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