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Mithra receives approval in France to market hormone replacement therapy Tibelia

Women's health specialist Mithra has received a marketing authorisation (MA) for the commercialisation of Tibelia in France.
Source: Pharmaceutical Technology - Category: Pharmaceuticals Source Type: news

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Breast cancer is the most frequent cancer among women especially in the Western world where, despite improved survival, it is one of the leading causes of death (1). Furthermore, for several decades there has been an increase in incidence, though recently there seems to be a stabilization in risk or even a small decline in typical high-risk areas such as Europe and the USA but at the same time a steep increase in typical low-risk societies such as Japan (2). Breast cancer is often regarded as a singular disease, but recent discoveries are pointing to a variety of types of potentially different etiology. Thus, the female...
Source: Scandinavian Journal of Work, Environment and Health - Category: Occupational Health Tags: Editorial Source Type: research
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print
Source: Journal of Pediatric Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Abstract Hot flushes affect 70% of menopausal women and are reported as being the most bothersome symptom by the majority. Hormone replacement therapy and other currently available alternative therapies are not without side-effects and/or have variable efficacy, and so an effective novel therapy could be practice-changing. Over the last 20 years, numerous studies in animal and human models have implicated neurokinin B, a hypothalamic neuropeptide, together with its receptor (NK3R) in the etiology of menopausal hot flushes. Most recently, a randomized, placebo-controlled trial of an NK3R antagonist in symptomatic m...
Source: Climacteric - Category: Geriatrics Authors: Tags: Climacteric Source Type: research
We report the case of a 27-year-old woman who is 3 months post-partum, breastfeeding, and suffering from Graves ’ disease hyperthyroidism treated first with methimazole and then with propylthiouracil due to a methimazole allergy. She was admitted for urosepsis and agranulocytosis. The patient was diagnosed with propylthiouracil related agranulocytosis, diffuse toxic goiter, and thyro-gastric syndrome. Antit hyroid drug therapy was stopped resulting in a worsening of thyrotoxicosis. Agranulocytosis was treated with 8 doses of G-CSF with full recovery. To rapidly restore euthyroidism and to perform a thyroidectomy, the...
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
We present an unusual case of SS in a young lady who continued to have normal menstruation after the index event, had two spontaneous pregnancies, and was diagnosed only 11 years later when she presented to us with acute heart failure.
Source: Journal of Postgraduate Medicine - Category: Internal Medicine Authors: Source Type: research
We describe postoperative complications after penile inversion vaginoplasty and evaluate age, BMI, and years on hormone replacement therapy (HRT) as risk factors for complications.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
MN, 50 years old, BMI: 36. Menopause was 7 years ago. No hormone replacement therapy before. She was treated for breast cancer and stopped using tamoxifen two years ago. Asymptomatic. She underwent to a screening transvaginal ultrasound that showed an endometrial thickness of 0.6  cm. Diagnostic hysteroscopy visualized two endometrial polyps. Surgical hysteroscopy was performed with The Integrated Bigatti Shaver (IBS®). The IBS® consists in a 6° angle telescope with an integrated sheath and a working channel in which a rigid shaver system is inserted.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Source Type: research
Authors: Gambacciani M, Biglia N, Cagnacci A, DI Carlo C, Caruso S, Cicinelli E, DE Leo V, Farris M, Gambera A, Guaschino S, Lanzone A, Paoletti AM, Russo N, Vicariotto F, Villa P, Volpe A Abstract In the last decade the risk benefits ratio of HRT has been reevaluated mainly in tens of cardiovascular risk. Present Consensus Statement is largely inspired by the Global Consensus on Menopausel Hormone Therapy in 2013 and 2016 by leading global menopause societies (The American Society for Reproductive Medicine, The Asia Pacific Menopause Federation, The Endocrine Society, The European Menopause and Andropause Society,...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
CONCLUSIONS: Overall, these results suggest that the combined application of E2 and P can be a new effective strategy for hormone replacement therapy after treatment of cervical adenocarcinoma. PMID: 28975965 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
A systematic review and meta-analysis were conducted to examine the effect of growth hormone replacement therapy (GHRT) on the recurrence of craniopharyngioma in children.
Source: World Neurosurgery - Category: Neurosurgery Authors: Tags: Literature Reviews Source Type: research
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