Risk of Ischemic Stroke Associated With Calcium Supplements With or Without Vitamin D: A Nested Case-Control Study Stroke

BackgroundThere is controversy surrounding the risk of ischemic stroke associated with the use of calcium supplements either in monotherapy or in combination with vitamin D.Methods and ResultsA nested case‐control study was performed with patients aged 40 to 89 years old, among whom a total of 2690 patients had a first episode of nonfatal ischemic stroke and for which 19 538 controls were randomly selected from the source population and frequency‐matched with cases for age, sex, and calendar year. Logistic regression provided the odds ratios while adjusting for confounding factors. A sensitivity analysis was performed by restricting to patients who were new users of calcium supplements as either monotherapy or with vitamin D. Calcium supplementation with vitamin D was not associated with an increased risk of ischemic stroke (odds ratio 0.85; 95% confidence interval, 0.67–1.08) in the population as a whole or under any of the conditions examined (dose, duration, background cardiovascular risk, sex, or age). Calcium supplement monotherapy was not associated with an increased risk in the population as a whole (odds ratio 1.18; 95% confidence interval, 0.86–1.61), although a significant increased risk at high doses (≥1000 mg/day: odds ratio 2.09; 95% confidence interval, 1.25–3.49;
Source: JAHA:Journal of the American Heart Association - Category: Cardiology Authors: Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Research Source Type: research

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Annu Rev Physiol. 2021 Oct 26. doi: 10.1146/annurev-physiol-060821-014521. Online ahead of print.ABSTRACTCerebral small vessel disease (SVD) is highly prevalent and a common cause of ischemic and hemorrhagic stroke and dementia, yet the pathophysiology is poorly understood. Its clinical expression is highly varied, and prognostic implications are frequently overlooked in clinics; thus, treatment is currently confined to vascular risk factor management. Traditionally, SVD is considered the small vessel equivalent of large artery stroke (occlusion, rupture), but data emerging from human neuroimaging and genetic studies refut...
Source: Annual Review of Physiology - Category: Physiology Authors: Source Type: research
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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
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Source: Psychiatr News - Category: Psychiatry Tags: cardiovascular problems heart attack JAMA Network Open off-label use older adults stimulants stroke transient ischemic attack ventricular arrhythmia Source Type: research
Condition:   Stroke, Ischemic Intervention:   Device: endovascular treatment Sponsor:   General Hospital of Shenyang Military Region Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Stroke, Acute Ischemic Interventions:   Drug: Mechanical thrombectomy;   Drug: medical treatment Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ischemic Stroke Intervention:   Sponsors:   University Hospital, Basel, Switzerland;   Swiss National Science Foundation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Stroke, Acute Ischemic Interventions:   Drug: Mechanical thrombectomy;   Drug: medical treatment Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Stroke, Ischemic Intervention:   Device: endovascular treatment Sponsor:   General Hospital of Shenyang Military Region Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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