Antibiotic prophylaxis for infective endocarditis: a systematic review and meta-analysis

Conclusions
The evidence base for the use of AP is limited, heterogeneous and the methodological quality of many studies is poor. Postprocedural bacteraemia is not a good surrogate endpoint for IE. Given the logistical challenges of a randomised trial, high-quality case–control studies would help to evaluate the role of dental procedures in causing IE and the efficacy of AP in its prevention.

Source: Heart - May 31, 2017 Category: Cardiology Authors: Cahill, T. J., Harrison, J. L., Jewell, P., Onakpoya, I., Chambers, J. B., Dayer, M., Lockhart, P., Roberts, N., Shanson, D., Thornhill, M., Heneghan, C. J., Prendergast, B. D. Tags: Valvular heart disease Source Type: research