A fifth of university professors take 'smart drugs'

Cambridge academic Dr Hannah Critchlow claims teachers are using drugs intended for Alzheimer's disease, narcolepsy and ADHD, which may cause heart problems and psychosis.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 21 July 2018Source: Brain, Behavior, and ImmunityAuthor(s): Steffen E. Storck, Anika M.S. Hartz, Jessica Bernard, Andrea Wolf, André Kachlmeier, Anne Mahringer, Sascha Weggen, Jens Pahnke, Claus U. PietrzikAbstractThe accumulation of neurotoxic amyloid-beta (Aβ) in the brain is a characteristic hallmark of Alzheimer's disease (AD). The blood-brain barrier (BBB) provides a large surface area and has been shown to be an important mediator for removal of brain Aβ. Both, the ABC transporter P-glycoprotein (ABCB1/P-gp) and the receptor low-density lipoprotein receptor-related ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
In conclusion, 4-PSQ protected against learning and memory impairment and anxiety in a mouse model of AD induced by Aβ, and anticholinesterase and antioxidant actions are involved in the pharmacological effect of the compound. PMID: 30021335 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
This study aimed to analyze the relationship between adult ADHD and risky riding behavior of motorcyclists.Methods: The community-based cross-sectional study was run on 340 motorcyclists in Bukan, during 2015 and 2016, using a cluster-random sampling in 7 areas of the city. Using the city map provided by Bukan ’s Health Center, the city was divided into 14 clusters according to the areas covered by health centers. Then, 7 clusters (out of 14) were selected randomly. To achieve the anticipated sample size, the data was collected from these 7 clusters. In this study, the data collection instruments were: standard Motor...
Source: Journal of Injury and Violence Research - Category: International Medicine & Public Health Source Type: research
CONCLUSIONS: These findings indicated that applying the population-specific brain atlas to neuroimaging studies may achieve higher accuracy in activation detection. This may have implications to the imaging study of neurodegenerative diseases. PMID: 30024411 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
This study aimed to evaluate the effects of sevoflurane on working memory of rats and to characterize functional connectivity between excitatory neurons in the prefrontal cortex (PFC) during working memory performance.Methods18-month-old and 3-month-old male SD rats were implanted with a multielectrode array in the PFC. After recovery from the surgery, the aged and adult rats were divided into sevoflurane group and control group, respectively. Rats in sevoflurane group were exposed to 1 minimum alveolar concentration (MAC) or 1.5 MAC sevoflurane for two hours. At day1, 3, and 7 after exposure, the effects of sevoflurane an...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 20 July 2018Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Natali Bozhilova, Giorgia Michelini, Jonna Kuntsi, Philip AshersonAbstractAttention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder associated with a range of mental health, neurocognitive and functional problems. Although the diagnosis is based on descriptions of behaviour, individuals with ADHD characteristically describe excessive spontaneous mind wandering (MW). MW in individuals with ADHD reflects constant mental activity which lacks topic stability and content consistency. Based on th...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
MULTI-TASK SPARSE SCREENING FOR PREDICTING FUTURE CLINICAL SCORES USING LONGITUDINAL CORTICAL THICKNESS MEASURES. Proc IEEE Int Symp Biomed Imaging. 2018 Apr;2018:1406-1410 Authors: Zhang J, Tu Y, Li Q, Caselli RJ, Thompson PM, Ye J, Wang Y Abstract Cortical thickness estimation performed in-vivo via magnetic resonance imaging (MRI) is an effective measure of brain atrophy in preclinical individuals at high risk for Alzheimer's disease (AD). However, the high dimensionality of individual cortical thickness data coupled with small population samples make it challenging to perform cortical thickness feat...
Source: Proceedings - International Symposium on Biomedical Imaging - Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research
Publication date: Available online 20 July 2018Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Yu Zhang, Yudan Zhao, Zhuoyi Wang, Hao Gong, Liang Ma, Dongsheng Sun, Chen Yang, Yang Li, Biao Cheng, Robert B. Petersen, Fengchao Jiang, Gongping Liu, Kun HuangAbstractProtein misfolding and aggregation are associated with amyloidosis. The toxic aggregation of amyloid-β 1–42 (Aβ42) may disrupt cell membranes and lead to cell death and is thus regarded as a contributing factor in Alzheimer's disease (AD). 1,4-naphthoquinone (NQ) has been shown to exhibit strong anti-aggregation effects on ...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Authors: Danek M, Danek J, Araszkiewicz A Abstract Many animal models in different species have been developed for mental and behavioral disorders. This review presents large animals (dog, ovine, swine, horse) as potential models of this disorders. The article was based on the researches that were published in the peer-reviewed journals. Aliterature research was carried out using the PubMed database. The above issues were discussed in the several problem groups in accordance with the WHO International Statistical Classification of Diseases and Related Health Problems 10thRevision (ICD-10), in particular regarding: ...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
s JP Abstract Histamine H3 receptor (H3R) is associated with several neuropsychological diseases. It is predominantly expressed in the central nervous system as presynaptic receptor, especially in regions associated with cognition and behavior, and is responsible for modulate the synthesis and release of histamine and other neurotransmitters such as acetylcholine, dopamine and serotonin. Therefore, H3R is an important target involved in several CNS disorders, such as narcolepsy, attention deficit hyperactivity disorder and schizophrenia. H3R antagonists/inverse agonists have also demonstrated pro-cognitive effects...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
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