HDAC9 is an epigenetic repressor of kidney angiotensinogen establishing a sex difference

ConclusionsThese results indicate that HDAC9 is a novel suppressing factor involved in AGT regulation in PTC, leading to low levels of intrarenal AGT in females. These findings will help to delineate mechanisms underlying sex differences in the development of hypertension and renin-angiotensin system (RAS) associated kidney injury.
Source: Biology of Sex Differences - Category: Biology Source Type: research