The relationship between sleep and glucagon ‐like peptide 1 in patients with abnormal glucose tolerance

This study aimed to explore the relationship between sleep and glucagon‐like peptide 1 regulation in patients with abnormal glucose tolerance. Seventy‐one adults with haemoglobin A1c levels between 5.7% and < 6.5% and no history of diabetes participated. Habitual sleep duration and efficiency were obtained from 7‐day actigraphy recordings. Obstructive sleep apnea was assessed using an overnight home monitor. Glucagon‐like peptide 1 levels were measured during a 75‐g glucose tolerance. The area under the curve of glucagon‐like peptide 1 was calculated. The mean age (SD) was 55.1 (8.3) years and median (interquartile range) haemoglobin A1c was 5.97% (5.86, 6.23). There was no relationship between sleep duration or efficiency and fasting or area under the curve glucagon‐like peptide 1. Glucagon‐like peptide 1 levels did not differ among those sleeping ≤ 5.75, > 5.75–< 6.5 or ≥ 6.5 h per night. Increasing apnea–hypopnea index, an indicator of obstructive sleep apnea severity, correlated with lower area under the curve glucagon‐like peptide 1 (B −0.242, P = 0.045), but not with fasting glucagon‐like peptide 1 (B −0.213, P = 0.079). After adjusting for sex, haemoglobin A1c and body mass index, increasing apnea–hypopnea index was negatively associated with having area under the curve glucagon‐like peptide 1 in the highest quartile (odds ratio 0.581, P = 0.028, 95% CI 0.359, 0.942). This study demonstrated that increasing obst...
Source: Journal of Sleep Research - Category: Neurology Authors: Tags: Regular Research Paper Source Type: research