At UAMS, Smeltzer Gets $11M to Study Pathogens

The University of Arkansas for Medical Sciences said Tuesday that Mark Smeltzer has been awarded $11 million in federal funding for Phase II of a program that supports microbiology and immunology research. Phase I of the Centers of Biomedical Research Excellence (COBRE) grant was awarded by the National Institutes of Health (NIH) in 2012 at $10 million. Phase II began May 1 and is $11 million. The first COBRE grant allowed Smeltzer to establish the UAMS Center for Microbial Pathogenesis and Host Inflammatory Responses. Its focus is pathogens – bacteria, viruses and microorganisms – and the disease responses they cause in humans. The latest award continues funding of the center, with individual projects on cancer, Lyme disease, pneumonic plague and chlamydial infection. Smeltzer and Richard P. Morrison, chairman of the Department of Microbiology and Immunology in the UAMS College of Medicine, co-direct the center. "Everything that we do, at the end of the day, it's really about human health," Smeltzer said in a news relesase. "We're trying to understand how microorganisms and pathogens cause disease in humans, and if you understand that, you’re that much closer to coming up with useful treatments." COBRE grants are only available for Institutional Development Award (IDeA) states where NIH funding has been historically low. UAMS is host to two other centers funded by COBRE grants: the Center for Translational Neuroscience, and the Center fo...
Source: Arkansas Business - Health Care - Category: American Health Source Type: news

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(DOE/Oak Ridge National Laboratory) A team of researchers from the Department of Energy's Oak Ridge National Laboratory (ORNL) Health Data Sciences Institute (HDSI) have harnessed the power of artificial intelligence (AI) to better match cancer patients with clinical trials. The researchers were one of ten teams to develop a digital tool to address complex challenges relevant to medical conditions such as cancer and Lyme disease as part of The Opportunity Project (TOP) Health Sprint.
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(VIB (the Flanders Institute for Biotechnology)) The immune system is composed of a wide range of different immune cells each with dedicated functions. Natural killer T cells form a specialized immune cell that protects against a variety of diseases such as cancer, autoimmunity, metabolic disease or certain infections such as Lyme disease
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This study identified fundraising campaigns for unsubstantiated treatments, such as homeopathic remedies for cancer and antibiotic therapy for chronic Lyme disease, on GoFundMe and other crowdfunding platforms.
Source: JAMA - Category: General Medicine Source Type: research
“Heart disease, stroke, cancer, diabetes, chronic Lyme disease, depression” – just some of the illnesses outlined by World Health Organization (WHO) chief Dr. Tedros Ghebreyesus, who drove home the danger by asking delegates to stand up, when they heard the name of an illness that had killed someone they loved: One by one, every single person in the room, got to their feet.
Source: UN News Centre - Health, Poverty, Food Security - Category: International Medicine & Public Health Source Type: news
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, we analyzed FGF21 levels and alterations in the expression of genes encoding components of the FGF21-responsive molecular machinery in adipose tissue from aged individuals so as to ascertain whether altered FGF21 responsiveness that develops with aging jeopardizes human health and/or accelerates metabolic disturbances associated with aging. We studied a cohort of 28 healthy elderly individuals (≥70 years) with no overt signs of metabolic or other pathologies and compared them with a cohort of 35 young healthy controls (≤40 years). Serum FGF21 levels were significantly increased in elderly indiv...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Research Source Type: news
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Source: Acupuncture and Electro-Therapeutics Research - Category: Complementary Medicine Tags: Acupunct Electrother Res Source Type: research
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