Statin use does not protect from fractures: the healthy adherer effect is a plausible explanation in observational studies

Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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Abstract Beyond being epiphenomenon of shared epidemiological factors, the integration of osteoporosis (OP) with cardiovascular disease (CVD)- termed "calcification paradox"- reflects a continuum of aberrant cardiometabolic status. The present review provides background knowledge on "calcification paradox", focusing on the endocrine aspect of vasculature orchestrated by the osteoblastic molecular fingerprint of vascular cells, acquired via imbalance among established modulators of mineralization. Osteoprotegerin (OPG)-the well-established osteoprotective cytokine-has recently been shown to exer...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
In this study, there was no increased risk of adverse outcomes (including muscle aches, liver dysfunction, new onset of diabetes, cancer, and bleeding strokes), even when LDL was lowered to as low as 20 mg/dL. Although statin medications themselves have been linked to side effects, especially at high doses, it appears that extremely low LDL concentrations are not responsible for side effects. In other words, lowering LDL beyond our previous target of 70 mg/dL appears to be not only safe but beneficial, in patients with CVD. The post LDL cholesterol: How low can you (safely) go? appeared first on Harvard Health Blog.
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Drugs and Supplements Health Heart Health Source Type: blogs
First study of its kind to show that although low doses of statins appear protective of bone health, high doses may increase risk for osteoporosis.Medscape Medical News
Source: Medscape Radiology Headlines - Category: Radiology Tags: Diabetes & Endocrinology News Source Type: news
THURSDAY, Oct. 10, 2019 -- There is a dose-dependent relationship between diagnosis of osteoporosis and statin treatment, according to a study published online Sept. 26 in Annals of the Rheumatic Diseases. Michael Leutner, M.D., from Medical...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Cholesterol-lowering statin drugs may affect osteoporosis risk, depending on the dose.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cholesterol Osteoporosis Statins (Cholesterol-Lowering Drugs) Source Type: news
An analysis of health data on 7.9 million people reveals lower rates of osteoporosis among low dose statin users and higher rates among high dose users.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Statins Source Type: news
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity Researchers her...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsThe characteristics of patients starting oral bisphosphonate therapy have changed over time. Consideration must be given to these time trends when designing studies that examine osteoporosis drug effects.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
CONCLUSION: Data for the effects of the abovementioned pharmacological substances could be found mostly in preclinical studies. The effects of these agents on bone healing in humans has currently not been studied or published. Therefore, the use of these drugs should be discussed carefully in cases with a compromised fracture healing. PMID: 31214745 [PubMed - as supplied by publisher]
Source: Der Unfallchirurg - Category: Orthopaedics Authors: Tags: Unfallchirurg Source Type: research
We examined the incidence rate and risk factors of osteoporotic vertebral fracture in RA patients with new-onset CVD (RA-CVD) and evaluated the effects of medications on such fracture risk.MethodsA retrospective study was conducted using a nationwide database from 2000 to 2010: 1267 RA-CVD and 1267 non-CVD patients were enrolled from 30,507 patients with newly diagnosed RA. The main outcome was the development of osteoporotic vertebral fracture. After being adjusted for age, gender, and comorbidities, the Cox proportional hazard model was used to identify independent factors contributing to osteoporotic vertebral fracture....
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
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