Skin nerve phosphorylated {alpha}-synuclein deposits in idiopathic REM sleep behavior disorder
Conclusions:
Our preliminary findings suggest that skin biopsy in patients with iRBD might be a safe and sensitive procedure to be further tested in order to detect p-α-syn deposits in the premotor stage of synucleinopathies.
Classification of evidence:
This study provides Class III evidence that p-α-syn skin deposits identify patients with iRBD.
Source: Neurology - Category: Neurology Authors: Antelmi, E., Donadio, V., Incensi, A., Plazzi, G., Liguori, R. Tags: All Movement Disorders, Parkinson's disease/Parkinsonism, All Sleep Disorders, Parasomnias ARTICLE Source Type: research
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