Skin nerve phosphorylated {alpha}-synuclein deposits in idiopathic REM sleep behavior disorder

Conclusions: Our preliminary findings suggest that skin biopsy in patients with iRBD might be a safe and sensitive procedure to be further tested in order to detect p-α-syn deposits in the premotor stage of synucleinopathies. Classification of evidence: This study provides Class III evidence that p-α-syn skin deposits identify patients with iRBD.
Source: Neurology - Category: Neurology Authors: Tags: All Movement Disorders, Parkinson's disease/Parkinsonism, All Sleep Disorders, Parasomnias ARTICLE Source Type: research