Neuroendocrine differentiation in basal cell carcinoma.

Neuroendocrine differentiation in basal cell carcinoma. J Immunoassay Immunochem. 2017 May 26;: Authors: Houcine Y, Chelly I, Zehani A, Belhaj Kacem L, Azzouz H, Rekik W, C H, Haouet S, Kchir N Abstract Basal cell carcinoma (BCC) is the prototypical basaloid tumour of the skin. It may show various patterns simulating other cutaneous tumours due to its pleomorphism. It may have unusal pattern of differentiaton such as squamous, sebaceous, apocrine, eccrine, pilar and endocrine differentiation. In order to establish the relative frequency of neuroendocrine differentiation in BCC, we performed a retrospective study of 33 consecutive BCCs using conventional immunohistochemistry with two neuroendocrine antibodies: Chromogranine A and synaptophysine. The age of the patients ranged from 17 to 83 years with mean of 65 years. The male to female ratio was 16: 17. In immunohistochimestry, Chromogranine A was seen in 72,2% (24/33) while Synaptophysine was positive in 9,09% (3/33). Their expression was cytoplasmic and membranous and was seen in the periphery of these tumors in the overlying cells. Positive staining of chromogranine A was high (75 to 100% of tumors cells) in 9%, intermediate (25 to 75% of tumors cells) in 33% of cases and relatively low (<25%) in 30,3% of cases. PMID: 28548901 [PubMed - as supplied by publisher]
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research