Regio- and Stereoselective Route to Bis-[3-methyl-1,1 ‘,4‘-triaryl-5-oxo-spiro-pyrazoline-4,5‘-pyrazoline] Derivatives via 1,3-Dipolar Cycloaddition under Sonication

Publication date: Available online 26 May 2017 Source:Arabian Journal of Chemistry Author(s): Haider Behbehani, Kamal M. Dawood, Hamada Mohamed Ibrahim, Noha S. Mostafa Bis-[3-methyl-1,1‘,4‘-triaryl-5-oxo-spiro-pyrazoline-4,5‘-pyrazoline] derivatives are synthesized regio- and stereoselectively via 1,3-dipolar cycloaddition of the bis-hydrazonoyl chlorides with 4-arylidenepyrazol-5-one derivatives. The cycloaddition route is optimized under both ultrasonic irradiation and conventional heating modes. The regio- and stereoselectivity of the cycloadducts are confirmed by spectral and X-ray crystallographic analysis. Graphical abstract
Source: Arabian Journal of Chemistry - Category: Chemistry Source Type: research