Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072.

In conclusion, BAL30072 is toxic for liver mitochondria and inhibits glycolysis at clinically relevant concentrations. Impaired hepatic mitochondrial function and inhibition of glycolysis can explain liver injury observed in human subjects receiving long-term treatment with this compound.
PMID: 28536862 [PubMed - as supplied by publisher]

Source: Archives of Toxicology - May 23, 2017 Category: Toxicology Authors: Paech F, Messner S, Spickermann J, Wind M, Schmitt-Hoffmann AH, Witschi AT, Howell BA, Church RJ, Woodhead J, Engelhardt M, Krähenbühl S, Maurer M Tags: Arch Toxicol Source Type: research