CD39 Limits P2X7 Receptor Inflammatory Signaling and Attenuates Sepsis-Induced Liver Injury

Sepsis is a leading cause of death in intensive care units worldwide [1] and represents a major public health issue, due to high numbers of deaths of economically productive people and major morbidity in survivors. Aspects of the associated morbidity and mortality are related to onset of shock and hemodynamic compromise with multiple system organ dysfunction and failure due to the excessive, unfettered inflammation [1,2].

Source: Journal of Hepatology - May 26, 2017 Category: Gastroenterology Authors: Luiz Eduardo Baggio Savio, Paola de Andrade Mello, Vanessa R. Figliuolo, Thiago F. de Avelar Almeida, Patr ícia T. Santana, Suellen D.S. Oliveira, Claudia L.M. Silva, Linda Feldbrügge, Eva Csizmadia, Richard D. Minshall, Maria Serena Longhi, Yan Wu, Sim Source Type: research