A new biflavonoid and a new triterpene from the leaves of Garcinia paucinervis and their biological activities

AbstractA new biflavonoid, paucinervin K (1) and a new triterpene, 23-hydroxy-friedelin (2), together with eleven known compounds3-13 were isolated from the leaves ofGarcinia paucinervis. Their structures, including stereochemistry, were determined by spectroscopic analysis of NMR, MS, IR and ECD calculation and the octant rule. Some of the isolated compounds were tested for antiproliferative,α-glucosidase inhibitory and antioxidant activities in vitro. Compounds1,3,4,5 and9 showed moderate preferential antioxidant and hypoglycemic activities. Compounds3–6 and9 exhibited potent growth inhibition against HepG-2 and PC-3 cell lines with IC50 values ranging from 1.02 −10.05 μM.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research