Can You Make Your Sperm Better? Probably.

Everyone understands that healthy eggs and sperm are required to conceive, right? So, it shouldn’t be a surprise when couples have trouble starting a family that male fertility plays a role – more often than most people realize. In fact, male factor infertility is the primary medical issue in about 25% of infertility cases and a contributing factor another 25% of the time. For years, it has often been assumed that problems getting pregnant were all about the female half of the couple. Thanks to extensive media coverage of research, sperm issues and the role of male infertility are now mainstream topics. Still, it’s often left up to women to initiate discussion and testing for their partners. A major reason for male infertility – approximately 50% – is a low sperm count. And up to 90% of male infertility cases are due to low sperm count, or poor quality sperm or both. Poor quality sperm may be misshapen, poor swimmers, have damaged DNA and more. Additional causes of male infertility can be attributed to a range of conditions including anatomical problems, hormonal imbalances, and genetic defects. Experts believe a low sperm count may sometimes be related to an elevated temperature in the testicles – the temperature in the groin area should be a couple of degrees cooler than the rest of the body for optimum sperm function. Reportedly, every degree above normal results in an approximate 40% decline in sperm quality. Exposure to excessive hea...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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In this study, MHC-1 and PDL-1 score in primary and metastatic tumor cells was evaluated in 43 gastric cancer patients with lymph node metastasis. According to our results, the primary tumor PDL-1 score was correlated with the number of metastatic lymph nodes (r = 0.258; p = 0.024) and primary tumor size (r = 0.341; p = 0.045). A similar correlation was found between the primary tumor PDL-1 score and the metastatic tumor PDL-1 score (r = 0.213; p = 0.015). In our study, MHC-1 was found to be higher in primary tumors than metastatic tumors, although not statistically significant (p = 0.054). The results of our study showed ...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Authors: McCarthy AJ, O'Reilly SM, Shanley J, Geraghty R, Ryan EJ, Cullen G, Sheahan K Abstract Background: As the malignant potential of sessile serrated lesions/polyps (SSL/Ps) and traditional serrated adenomas (TSAs) has been clearly demonstrated, it is important that serrated polyps are identified and correctly classified histologically. Aim: Our aim was to characterize the clinicopathological features of a series of SSL/Ps &TSAs, to assess the accuracy of the pathological diagnosis, the incidence, and the rate of dysplasia in SSL/Ps &TSAs. Methods: We identified all colorectal serrated polyps b...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Comparing the role of anti-Müllerian hormone as a marker of FSH action in male and female fertility. Expert Rev Endocrinol Metab. 2019 Mar 04;:1-12 Authors: Urrutia M, Grinspon RP, Rey RA Abstract INTRODUCTION: Originally limited to the assessment of disorders of sex development, anti-Müllerian hormone (AMH) measurement has more recently been extended to several conditions affecting the reproductive axis in males and females. Follicle-stimulating hormone (FSH) regulation of gonadal function has been extensively studied, but its role on AMH production has been explored only recently. Areas cov...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Claudio de Lucia, Celestino Sardu, Laurent Metzinger, Coert J. Zuurbier
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Publication date: Available online 18 March 2019Source: Molecular Aspects of MedicineAuthor(s): Laura Valle, Richarda M. de Voer, Yael Goldberg, Wenche Sjursen, Asta Försti, Clara Ruiz-Ponte, Trinidad Caldés, Pilar Garré, Maren F. Olsen, Margareta Nordling, Sergi Castellvi-Bel, Kari HemminkiAbstractThe present article summarizes recent developments in the characterization of genetic predisposition to colorectal cancer (CRC). The main themes covered include new hereditary CRC and polyposis syndromes, non-CRC hereditary cancer genes found mutated in CRC patients, strategies used to identify novel causal ge...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Publication date: March 2019Source: Biomolecular Detection and Quantification, Volume 17Author(s): Abel Jacobus Bronkhorst, Vida Ungerer, Stefan HoldenriederAbstractAn increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and monitoring. However, harnessing the full potential of cfDNA requires (i) the optimization and standardization of preanalytical steps, (ii) refinement of current analysis strategies, and, perhaps most importantly, (iii) significant improvements in our understanding of its origin, phys...
Source: Biomolecular Detection and Quantification - Category: Molecular Biology Source Type: research
Publication date: Available online 18 March 2019Source: Redox BiologyAuthor(s): Jiawei Yin, Xiaoqian Wang, Shuzhen Li, Yalun Zhu, Sijing Chen, Peiyun Li, Cheng Luo, Yue Huang, Xiaoqin Li, Xueting Hu, Wei Yang, Wei Bao, Zhilei Shan, Liegang LiuAbstractAimsTo examine the associations of plasma copper concentrations and superoxide dismutase 1 (SOD1) polymorphisms as well as their gene-environment interaction with newly diagnosed impaired glucose regulation (IGR) and type 2 diabetes (T2D).MethodsWe performed a large case-control study in 2520 Chinese Han subjects: 1004 newly diagnosed T2D patients, 512 newly diagnosed IGR pati...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 18 March 2019Source: Life SciencesAuthor(s): Jing Zhang, Peng Cao, Jingjing Gui, Xin Wang, Jun Han, Yuwei Wang, Guodong WangAbstractAimsDiabetic nephropathy (DN) is the most common complication of diabetes mellitus. Endoplasmic reticulum (ER) plays an important role in the development and progression of DN. Arctigenin (ATG), a lignan extract from Fructus Arctii, exhibits anti-inflammatory, anticarcinogenic, anti-oxidative stress and immunomodulatory properties. The present research aimed to investigate whether ATG could protect against diabetes-related renal injury and inhibit ER stress i...
Source: Life Sciences - Category: Biology Source Type: research
ConclusionLong non-coding RNA MALAT1 sponged miR-195 to regulate proliferation, apoptosis and migration and immune escape abilities of DLBCL by regulation of PD-L1.
Source: Life Sciences - Category: Biology Source Type: research
Publication date: February 2019Source: Biomedical and Environmental Sciences, Volume 32, Issue 2Author(s): Meng Si QIU, Xian Wei WANG, Yan YAO, Si Qi GE, Hua Min LIU, Ying Chun DAI, Yong ZHOUAbstractObjectiveThe Jidong Women Health Cohort Study is a prospective cohort study on female-specific characteristics and risks of chronic diseases in Chinese women and focuses on the potential association between menopause and risks of cardiovascular disease (CVD).MethodsThe study includes 4,179 female participants with an age of older than 18 years from Caofeidian district, Tangshan city, northern China. Baseline information on fema...
Source: Biomedical and Environmental Sciences - Category: Biomedical Science Source Type: research
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