Can You Make Your Sperm Better? Probably.

Everyone understands that healthy eggs and sperm are required to conceive, right? So, it shouldn’t be a surprise when couples have trouble starting a family that male fertility plays a role – more often than most people realize. In fact, male factor infertility is the primary medical issue in about 25% of infertility cases and a contributing factor another 25% of the time. For years, it has often been assumed that problems getting pregnant were all about the female half of the couple. Thanks to extensive media coverage of research, sperm issues and the role of male infertility are now mainstream topics. Still, it’s often left up to women to initiate discussion and testing for their partners. A major reason for male infertility – approximately 50% – is a low sperm count. And up to 90% of male infertility cases are due to low sperm count, or poor quality sperm or both. Poor quality sperm may be misshapen, poor swimmers, have damaged DNA and more. Additional causes of male infertility can be attributed to a range of conditions including anatomical problems, hormonal imbalances, and genetic defects. Experts believe a low sperm count may sometimes be related to an elevated temperature in the testicles – the temperature in the groin area should be a couple of degrees cooler than the rest of the body for optimum sperm function. Reportedly, every degree above normal results in an approximate 40% decline in sperm quality. Exposure to excessive hea...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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AbstractAutophagy is crucial for the removal of dysfunctional organelles and protein aggregates and for maintaining stem cell homeostasis, which includes self-renewal, cell differentiation and somatic reprogramming. Loss of self-renewal capacity and pluripotency is a major obstacle to stem cell-based therapies. It has been reported that autophagy regulates stem cells under biological stimuli, starvation, hypoxia, generation of reactive oxygen species (ROS) and cellular senescence. On the one hand, autophagy is shown to play roles in self-renewal by co-function with the ubiquitin-proteasome system (UPS) to promote pluripote...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
Publication date: 18 October 2018Source: Cell, Volume 175, Issue 3Author(s): Kaiwei Liang, Edwin R. Smith, Yuki Aoi, Kristen L. Stoltz, Hiroaki Katagi, Ashley R. Woodfin, Emily J. Rendleman, Stacy A. Marshall, David C. Murray, Lu Wang, Patrick A. Ozark, Rama K. Mishra, Rintaro Hashizume, Gary E. Schiltz, Ali ShilatifardSummaryThe super elongation complex (SEC) is required for robust and productive transcription through release of RNA polymerase II (Pol II) with its P-TEFb module and promoting transcriptional processivity with its ELL2 subunit. Malfunction of SEC contributes to multiple human diseases including cancer. Here...
Source: Cell - Category: Cytology Source Type: research
Publication date: 18 October 2018Source: Cell, Volume 175, Issue 3Author(s): Vishal Singh, Beng San Yeoh, Benoit Chassaing, Xia Xiao, Piu Saha, Rodrigo Aguilera Olvera, John D. Lapek, Limin Zhang, Wei-Bei Wang, Sijie Hao, Michael D. Flythe, David J. Gonzalez, Patrice D. Cani, Jose R. Conejo-Garcia, Na Xiong, Mary J. Kennett, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-KumarSummaryDietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. Accordingly, consumption of such fibers ameliorates metabolic syndrome. However, incorporati...
Source: Cell - Category: Cytology Source Type: research
Publication date: 18 October 2018Source: Cell, Volume 175, Issue 3Author(s): David A. Quigley, Ha X. Dang, Shuang G. Zhao, Paul Lloyd, Rahul Aggarwal, Joshi J. Alumkal, Adam Foye, Vishal Kothari, Marc D. Perry, Adina M. Bailey, Denise Playdle, Travis J. Barnard, Li Zhang, Jin Zhang, Jack F. Youngren, Marcin P. Cieslik, Abhijit Parolia, Tomasz M. Beer, George Thomas, Kim N. Chi
Source: Cell - Category: Cytology Source Type: research
Publication date: Available online 18 October 2018Source: CellAuthor(s): Nazar Mashtalir, Andrew R. D’Avino, Brittany C. Michel, Jie Luo, Joshua Pan, Jordan E. Otto, Hayley J. Zullow, Zachary M. McKenzie, Rachel L. Kubiak, Roodolph St. Pierre, Alfredo M. Valencia, Steven J. Poynter, Seth H. Cassel, Jeffrey A. Ranish, Cigall KadochSummaryMammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling complexes are multi-subunit molecular machines that play vital roles in regulating genomic architecture and are frequently disrupted in human cancer and developmental disorders. To date, the modular organization and pathw...
Source: Cell - Category: Cytology Source Type: research
Publication date: Available online 18 October 2018Source: CellAuthor(s): Matthew M. Gubin, Ekaterina Esaulova, Jeffrey P. Ward, Olga N. Malkova, Daniele Runci, Pamela Wong, Takuro Noguchi, Cora D. Arthur, Wei Meng, Elise Alspach, Ruan F.V. Medrano, Catrina Fronick, Michael Fehlings, Evan W. Newell, Robert S. Fulton, Kathleen C.F. Sheehan, Stephen T. Oh, Robert D. Schreiber, Maxim N. ArtyomovSummaryAlthough current immune-checkpoint therapy (ICT) mainly targets lymphoid cells, it is associated with a broader remodeling of the tumor micro-environment. Here, using complementary forms of high-dimensional profiling, we define d...
Source: Cell - Category: Cytology Source Type: research
Publication date: Available online 18 October 2018Source: CellAuthor(s): Aleksandra Wroblewska, Maxime Dhainaut, Benjamin Ben-Zvi, Samuel A. Rose, Eun Sook Park, El-Ad David Amir, Anela Bektesevic, Alessia Baccarini, Miriam Merad, Adeeb H. Rahman, Brian D. BrownSummaryCRISPR pools are being widely employed to identify gene functions. However, current technology, which utilizes DNA as barcodes, permits limited phenotyping and bulk-cell resolution. To enable novel screening capabilities, we developed a barcoding system operating at the protein level. We synthesized modules encoding triplet combinations of linear epitopes to ...
Source: Cell - Category: Cytology Source Type: research
DISCUSSION: The routine PE of FH specimens after arthroplasty for femoral neck fractures is not warranted and uneconomic. Sending the FH for PE, only when clinically indicated, rather than routine, will result in notable savings for the healthcare system. LEVEL OF EVIDENCE: Level IV. PMID: 30334845 [PubMed - as supplied by publisher]
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
Source: Sleep Medicine - Category: Sleep Medicine Source Type: research
[The Herald] The thought of having to roll one's crown jewels between their fingers for a while in testicular cancer self-testing would make someone go, well, nuts . . . excuse the pun.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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