Can You Make Your Sperm Better? Probably.

Everyone understands that healthy eggs and sperm are required to conceive, right? So, it shouldn’t be a surprise when couples have trouble starting a family that male fertility plays a role – more often than most people realize. In fact, male factor infertility is the primary medical issue in about 25% of infertility cases and a contributing factor another 25% of the time. For years, it has often been assumed that problems getting pregnant were all about the female half of the couple. Thanks to extensive media coverage of research, sperm issues and the role of male infertility are now mainstream topics. Still, it’s often left up to women to initiate discussion and testing for their partners. A major reason for male infertility – approximately 50% – is a low sperm count. And up to 90% of male infertility cases are due to low sperm count, or poor quality sperm or both. Poor quality sperm may be misshapen, poor swimmers, have damaged DNA and more. Additional causes of male infertility can be attributed to a range of conditions including anatomical problems, hormonal imbalances, and genetic defects. Experts believe a low sperm count may sometimes be related to an elevated temperature in the testicles – the temperature in the groin area should be a couple of degrees cooler than the rest of the body for optimum sperm function. Reportedly, every degree above normal results in an approximate 40% decline in sperm quality. Exposure to excessive hea...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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A novel strategy of EGFR‑TKI combined chemotherapy in the treatment of human lung cancer with EGFR‑sensitive mutation. Oncol Rep. 2018 Jun 18;: Authors: Zhang L, Qi Y, Xing K, Qian S, Zhang P, Wu X Abstract The discovery of epidermal growth factor receptor (EGFR)‑sensitive mutations in non‑small cell lung cancer (NSCLC) and the successful clinical application of EGFR tyrosine kinase inhibitors (TKIs) have changed the regimen of lung cancer therapy from traditional cytotoxic chemotherapy to molecular‑targeted cancer therapy. However, the main limitation of EGFR‑TKI therapy is the hetero...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Tamura H, Higa A, Hoshi H, Hiyama G, Takahashi N, Ryufuku M, Morisawa G, Yanagisawa Y, Ito E, Imai JI, Dobashi Y, Katahira K, Soeda S, Watanabe T, Fujimori K, Watanabe S, Takagi M Abstract Patient-derived tumor xenograft models represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture; however, their use is low-throughput and costly. To overcome this limitation, patient-derived tumor organoids (PDOs) were established from human lung, ovarian and uterine tumor tissues, among others, to accurately and efficiently recapitulate the tissue architecture...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
This study is aimed to investigate the association between EPHA3 expression and androgen receptor (AR) signaling and the potential mechanism. We determined mRNA and protein levels of EPHA3 and AR signaling‑related genes in the PCa cell line 22Rv1 by reverse transcription‑polymerase chain reaction (RT‑PCR) and western blotting, respectively. The EPHA3 mRNA and protein levels were both found to be elevated by dihydrotestosterone (DHT) hormone in a dose‑ and time‑dependent manner, as AR and prostate‑specific antigen (PSA) expression were increased. Similarly, EPHA3 protein levels were also increased in the PCa cel...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
SB225002 inhibits prostate cancer invasion and attenuates the expression of BSP, OPN and MMP‑2. Oncol Rep. 2018 Jun 18;: Authors: Xu M, Jaing H, Wang H, Liu J, Liu B, Guo Z Abstract The mechanisms of malignant cell metastasis to secondary sites are complex and multifactorial. Studies have demonstrated that small integrin‑binding ligand N‑linked glycoproteins (SIBLINGs), particularly bone sialoprotein (BSP) and osteopontin (OPN), are involved in neoplastic growth and metastasis. SIBLINGs promote malignant cell invasion and metastasis by enhancing matrix metalloproteinase 2 (MMP‑2) and MMP‑9 ex...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
In conclusion, CAF‑derived HGF promotes angiogenesis, VM and mosaic vessel formation via PI3K/AKT and ERK1/2 signaling in gastric cancer and HGF may serve as a potential therapeutic target for cancer anti‑vascular treatment. PMID: 29917165 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Wang Y, Lin X, Fu X, Yan W, Lin F, Kuang P, Luo Y, Lin E, Hong X, Wu G Abstract Thyroid cancer is one of the most common malignant tumors of the endocrine system. Among all thyroid cancers, papillary thyroid carcinoma (PTC) is the most common type. The BRAF-activated non-coding RNA (BANCR) is a 693-bp nucleotide transcript which was first identified in melanoma. However, the role of BANCR in the development of thyroid cancer remains unclear. Therefore, the present study investigated the potential involvement of BANCR in the development of thyroid cancer in vitro using patient tissue samples and a pane...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Sun Y, Jiang F, Pan Y, Chen X, Chen J, Wang Y, Zheng X, Zhang J Abstract X‑box‑binding protein 1 (XBP1) contributes to various types of cancer including breast, bladder cancer and esophageal squamous cell carcinoma. The aim of the study was to examine the metastatic role of XBP1 in oral squamous cell carcinoma (OSCC), and identify possible downstream molecules. Immunohistochemical staining was conducted on tissue microarrays comprising 96 OSCC cases to determine the expression level of XBP1 and analyze its association with metastasis, clinicopathological characteristics and survival prognosis. Compared...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Zhang XH, Yang L, Liu XJ, Zhan Y, Pan YX, Wang XZ, Luo JM Abstract Suppressor of cytokine signaling‑1 (SOCS1) is a widely recognized tumor suppressor gene. Silencing of SOCS1 expression as a result of promoter methylation is associated with occurrence and development of solid tumors such as liver, cervical and pancreatic cancer. However, the association between SOCS1 gene methylation and acute myeloid leukemia (AML) has not been well explored. In the present study, we examined whether gene expression and methylation status of SOCS1 was altered in AML, and whether this was related to disease occurrence an...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Once-weekly dulaglutide is effective for glycemic control in patients with type 2 diabetes and moderate to severe kidney disease, while helping to slow renal function decline, new research shows.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
This month, the Pablove Foundation hung the photography of some of its young students on the walls of a Los Angeles gallery, giving viewers a look at how kids cope with cancer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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