Minimally-invasive Sampling of Interleukin-1 α and Interleukin-1 Receptor Antagonist from the Skin: A Systematic Review of in Vivo Studies in Humans.

Minimally-invasive Sampling of Interleukin-1 α and Interleukin-1 Receptor Antagonist from the Skin: A Systematic Review of in Vivo Studies in Humans. Acta Derm Venereol. 2017 May 24;: Authors: Falcone D, Spee P, van de Kerkhof PCM, van Erp PEJ Abstract Interleukin-1α (IL-1α) and its receptor antagonist IL-1RA play a pivotal role in skin homeostasis and disease. Although the use of biopsies to sample these cytokines from human skin is widely employed in dermatological practice, knowledge about less invasive, in vivo sampling methods is scarce. The aim of this study was to provide an overview of such methods by systematically reviewing studies in Medline, EMBASE, Web of Science and Cochrane Library using combinations of the terms "IL-1α", IL-1RA", "skin", "human", including all possible synonyms. Quality was assessed using the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) checklist. The search, performed on 14 October 2016, revealed 10 different sampling methods, with varying degrees of invasiveness and wide application spectrum, including assessment of both normal and diseased skin, from several body sites. The possibility to sample quantifiable amounts of cytokines from human skin with no or minimal discomfort holds promise for linking clinical outcomes to molecular profiles of skin inflammation. PMID: 28536733 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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UW Health, the academic medical center and health system of the University of Wisconsin-Madison, is using a new approach to computed tomography (CT) guided procedures. It is the first U.S. hospital to acquire the Imactis CT-Navigation system, which can be used during percutaneous interventional radiological procedures performed under CT such as tumor ablations, biopsies, musculoskeletal interventions, and other needle-based interventions, Imactis reported in a news release. With the Imactis CT-Navigation system, a “radiologist can select and check a needle’s planned trajectory in real ti...
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Pemphigus foliaceus (PF) is one of the two main forms of pemphigus and is characterized by circulating IgG to the desmosomal cadherin desmoglein 1 (DSG1) and by subcorneal blistering of the skin. The pathomechanism of blister formation in PF is unknown. Previously we have shown that PF IgG induces aggregation of DSG1, plakoglobin (PG), and IgG outside of desmosomes, what in immunofluorescence of PF patient skin visualizes as a granular IgG deposition pattern with a limited number of coarse IgG aggregates between cells. Here we have investigated the fate of these aggregates in skin and found that these are cleared by endocy...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Dermatology Source Type: forums
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Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
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Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
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Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Authors: Sorour NE, Hamed AM, Tabl HAM, Ahmed AAA Abstract Background: Common warts are caused by human papillomaviruses (HPVs), they are among the most common cutaneous viral infections. Macrophage migration inhibitory factor (MIF) is an essential contributor in many inflammatory and immune skin diseases. Yet, its role in the pathology of common warts is unclear. Objective: To assess MIF levels in lesional and perilesional skin in patients with common warts in comparison to apparently healthy control group with matching age and sex. Subjects and methods: A case-control study performed on 60 patients with c...
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
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Source: Parasitology International - Category: Parasitology Source Type: research
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Source: Dermatology Online Journal - Category: Dermatology Source Type: research
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Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
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