Livedo Reticularis on the Lower Limbs in a Patient with Lupus Erythematosus: A Quiz.
Livedo Reticularis on the Lower Limbs in a Patient with Lupus Erythematosus: A Quiz. Acta Derm Venereol. 2017 May 24;: Authors: Miquelestorena-Standley E, Saleh A, Lataste A, Monegier Du Sorbier C, Machet L PMID: 28536734 [PubMed - as supplied by publisher]
Authors: Li S, Di D, Wu X, Zhang L, Liu R, Huang Q, Pan H, Ye D, Leng R Abstract Recent large-scale genetic association studies have identified that several single nucleotide polymorphisms (SNPs) on X chromosome are correlated with risk of systemic lupus erythematosus (SLE) in Chinese population. The aim of this study was to estimate association between these loci and clinical features in female patients with SLE. Six SNPs identified in previous studies were genotyped. Odds ratio (OR) was calculated with adjusting for potential confounding factors. A total of 772 SLE patients were included in the final analysis. Th...
We report loss of epigentic silencing marks on the inactive X on female mice with lupus like disease, and find novel sex differences in gene expression between female and male mice with late stage disease.
AstraZeneca Plc said on Monday its experimental treatment anifrolumab significantly reduced disease activity in patients with systemic lupus erythematosus (SLE) in its late-stage study TULIP-2 study.Reuters Health Information
AstraZeneca reported positive results this week from a late-stage lupus study.
Abstract Sex hormones are best known for their influences on reproduction, but they also have profound influences on the immune response. Examples of sex-specific differences include: (i) the relatively poor control of influenza virus infections in males compared to females, (ii) allergic asthma, an IgE-associated hypersensitivity reaction that is exacerbated in adolescent females compared to males, and (iii) systemic lupus erythematosus, a life-threatening autoimmune disease with a 9:1 female:male bias. Here we consider how estrogen and estrogen receptor α (ERα) may influence the immune response by mo...
Authors: Ziaie S, Moradi O, Saffaei A PMID: 31705754 [PubMed - in process]
We report an adolescent girl with SLE, autoimmune thyroiditis and distal RTA who subsequently developed autoimmune hemolytic anemia. During a follow up of almost 7 years the girl never developed any proteinuria while the RTA persisted. Also during this period her mother was also diagnosed with SLE manifesting as thrombocytopenia. PMID: 31705751 [PubMed - in process]
ConclusionsWe found a high frequency ofH. pylori infection in SLE patients. The severity of SLE and reception of gastroprotective therapy do not seem to be related toH. pylori infection. Immunosuppressive therapy may not be protective againstH. pylori infection in SLE patients.Key Points•In patients with systemic lupus erythematosus (SLE), the frequency of Helicobacter pylori infection was 39% and gastric erosions were frequent.•Disease activity, chronic damage, gastroprotective drugs, and immunosuppressive therapy may not affect the prevalence of H. pylori infection in SLE patients.
Conclusions: Altogether, low-grade systemic inflammation that influenced SLE disease activity and severity was correlated to dysbiotic changes of the oral microbiota present in periodontal diseases.
AstraZeneca Plc said on Monday its experimental treatment significantly reduced disease activity in patients with autoimmune disorder lupus, in a late-stage study.