Sedentary behaviour and bone health in children, adolescents and young adults: a systematic review

AbstractSedentary behaviour (SB) is increasing in Western societies and some studies suggest a deleterious effect of SB on bone. The aim of this systematic review was to examine the association between SB and bone health in children, adolescents and young adults. Electronic databases (PubMed, MEDLINE, PsycINFO and Science Citation Index) were searched for relevant articles up to January 9, 2017. Studies were included when results on bone health (e.g. strength, mass and structure) and either subjectively (questionnaires) or objectively (accelerometry) measured SB were reported in healthy participants ≤24 years. Two reviewers independently screened titles and abstracts for eligibility, rated methodological quality and extracted data. Seventeen observational studies were included. Several studies that used DXA or quantitative ultrasound suggested that objectively measured SB was negatively asso ciated with lower extremity bone outcomes, such as femoral neck bone mineral density. The magnitude of this negative association was small and independent of moderate-to-vigorous physical activity. In contrast to the lower extremities, there was insufficient evidence for an association of lumbar spi ne bone outcomes with objectively measured SB. In high-quality studies that used DXA, no association was observed between objectively measured SB and total body bone outcomes. In studies using questionnaires, none of these relationships were observed. Well-designed longitudinal studies...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

Related Links:

AbstractPurpose of ReviewThe goals of this review are two folds: (1) to describe the recent understandings on the roles of calcitonin gene-related peptide- α (CGRP) in bone homeostasis and the underlying mechanisms of related neuronal regulation and (2) to propose innovative CGRP-modulated approaches for enhancing bone regeneration in challenging bone disorders.Recent FindingsCGRP is predominantly produced by the densely distributed sensory neuronal fibers in bone, declining with age. Under mechanical and biochemical stimulations, CGRP releases and exerts either physiological or pathophysiological roles. CGRP at phys...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
CONCLUSION: In absence of guidelines for GPHPT management, its treatment should be individualized. In our case, despite high calcium levels, a conservative treatment with strict monitoring led to positive outcome of pregnancy. PMID: 33030137 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Endocrinology Authors: Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Semin Musculoskelet Radiol 2020; 24: 337-354 DOI: 10.1055/s-0040-1708823Radiologic imaging is crucial for diagnosing and monitoring rheumatic inflammatory diseases. Particularly the emerging approach of precision medicine has increased the interest in quantitative imaging. Extensive research has shown that ultrasound allows a quantification of direct signs such as bone erosions and synovial thickness. Dual-energy X-ray absorptiometry and high-resolution peripheral quantitative computed tomography (CT) contribute to the quantitative assessment of secondary signs such as osteoporosis or lean mass loss. Magnetic resonance ima...
Source: Seminars in Musculoskeletal Radiology - Category: Radiology Authors: Tags: Review Article Source Type: research
Authors: Kutsal FY, Ergİn Erganİ GO Abstract Vertebral compression fracture is a hallmark of osteoporosis and by far and away the most prevalent fragility fracture. It is well proven that, patients who develop a vertebral compression fracture are at substantial risk for additional fractures. Diagnosis is based on adequate clinical evaluation, imaging and laboratory tests. Imaging of osteoporosis and fragility fractures includes conventional radiology to evaluate spinal fractures, bone mineral density testing by dual energy x ray densitometry, quantitative computerized tomography, magnetic resonance imaging, bone ...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
This study protocol has been approved by the Ethics Committee of the University of Salamanca. The results will be published in peer-reviewed journals and disseminated in national and international conferences, to the participants and their families, and the general public through the associations of people with AD. Trial registration ID: ClínicalTrials.gov ID: NCT04439097.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
We report a rare case of bilateral atypical ulnar fractures in an 86-year-old woman with osteoporosis who finished the treatment with teriparatide for 2 years after long-term treatment with BP. She slid down from an approximately 30-cm-tall seat and slightly contused her left elbow. Plain radiography revealed that both ulnae had a noncomminuted short oblique fracture with cortical thickening and sclerosis at the fracture site. Based on the clinical and radiological findings, she was diagnosed with bilateral atypical ulnar fractures. The fracture of the left ulna was completely displaced and treated surgically. On the other...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Authors: Atiase Y, Quarde A Abstract Data abounds on osteoporosis in developed countries unlike developing countries, particularly those in sub-Saharan Africa. This review was done to confirm the paucity of data the authors suspected and to encourage studies in this field. AJOL (African Journals Online), MEDLINE and EMBASE databases were searched for studies published from January 1980 to August 2018. The eligibility criteria for inclusion were observational studies evaluating osteoporosis prevalence or incidence rates of fragility fractures. Out of 1,170 articles identified, six met the eligibility criteria. Preva...
Source: Ghana Medical Journal - Category: African Health Tags: Ghana Med J Source Type: research
Socioeconomic status can help predict whether a person will die from heart...Read more on AuntMinnie.comRelated Reading: COVID-19 patients at risk for heart complications Cardiac CT shows promise for osteoporosis screening Breast cancer mortality higher after heart attack Echocardiography reveals heart changes in WNBA players DiA gets FDA nod, CE Mark for AI-based ultrasound tools
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Authors: Heydenreich J, Schweter A, Lührmann P Abstract BACKGROUND: Bone density in the young-adult life is associated with risk for osteoporosis in later life. Next to genetic factors, lifestyle seems to play an important role for bone health. Purpose of the study was to clarify the relationship between various lifestyle factors and bone parameters in university students. METHODS: In 233 women and 52 men (age: 22.7±3.1 vs. 24.0±3.2 years; BMI: 22.2±2.9 vs. 24.2±3.1 kg∙m-2) the following parameters were assessed: calcaneal stiffness index (SI; quantitative ultrasound), body co...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
This study aims to identify novel genetic loci associated with DXA-derived femoral neck (FNK) bone mineral density (BMD) and quantitative ultrasound of the heel calcaneus estimated BMD (eBMD), and to detect shared/causal variants for the two traits, to assess whether the SNPs or putative causal SNPs associated with eBMD were also associated with FNK-BMD.MethodsNovel loci associated with eBMD and FNK-BMD were identified by the genetic pleiotropic conditional false discovery rate (cFDR) method. Shared putative causal variants between eBMD and FNK-BMD and putative causal SNPs for each trait were identified by the colocalizati...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
More News: Children | Databases & Libraries | Orthopaedics | Osteoporosis | Science | Study | Ultrasound