Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation

The neuronal substrate for binge eating, which can at times lead to obesity, is not clear. We find that optogenetic stimulation of mouse zona incerta (ZI) -aminobutyric acid (GABA) neurons or their axonal projections to paraventricular thalamus (PVT) excitatory neurons immediately (in 2 to 3 seconds) evoked binge-like eating. Minimal intermittent stimulation led to body weight gain; ZI GABA neuron ablation reduced weight. ZI stimulation generated 35% of normal 24-hour food intake in just 10 minutes. The ZI cells were excited by food deprivation and the gut hunger signal ghrelin. In contrast, stimulation of excitatory axons from the parasubthalamic nucleus to PVT or direct stimulation of PVT glutamate neurons reduced food intake. These data suggest an unexpected robust orexigenic potential for the ZI GABA neurons.
Source: ScienceNOW - Category: Science Authors: Tags: Neuroscience reports Source Type: news

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Publication date: Available online 15 July 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Marta G. Novelle, Carlos DiéguezAbstractIn an obesity pandemic context, eating disorders (ED) have arisen as serious illnesses associated with severe disturbances and has a clear gender dependent bias. In this manuscript, we provide an overview of the oestrogen role in the homeostatic and hedonic control of food intake. We draw attention to the role of oestrogens in the various reward processes and their possible implication in the development of ED, a condition much more common in women. In here, we have summarized...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
Abstract PURPOSES: Aberrant eating patterns are frequently observed in bariatric patients. Since bariatric operations produce alterations in food transit and in appetite/satiety balance, postoperative eating behavior changes are not surprising. METHODS: 88 consecutive obese patients undergoing Roux-en-Y gastric bypass (RYGBP, 50 cases) and Sleeve Gastrectomy (SG, 38 cases) were retrospectively evaluated. Beside anthropometric data measurement, eating behavior was assessed by direct interview prior to the operation and at the first and second postoperative years: patients were considered as eating disordered (...
Source: Eating and weight disorders : EWD - Category: Eating Disorders & Weight Management Authors: Tags: Eat Weight Disord Source Type: research
CONCLUSIONS: Impaired Autonomy and Performance is associated with BED in a sample of obese patients. Schema therapy should be considered a potential psychotherapy strategy in the treatment of BED. LEVEL OF EVIDENCE: Level III, case-control study. PMID: 31302882 [PubMed - as supplied by publisher]
Source: Eating and weight disorders : EWD - Category: Eating Disorders & Weight Management Authors: Tags: Eat Weight Disord Source Type: research
CONCLUSION: Our results confirm that both FA and clinical level of binge eating are common problems in both overweight/obese patients seeking low-energy-diet therapy and in obese bariatric surgery candidates, justifying the clinical utility of assessing these dysfunctional eating patterns. PMID: 31282493 [PubMed - in process]
Source: Rivista di Psichiatria - Category: Psychiatry Tags: Riv Psichiatr Source Type: research
Authors: Cuellar-Barboza AB, Winham SJ, Biernacka JM, Frye MA, McElroy SL Abstract INTRODUCTION: The clinical and genetic study of psychiatric conditions has underscored the co-occurrence of complex phenotypes and the need to refine them in entities that are more precise. Bipolar Disorder (BD) and Binge Eating (BE) behavior are common psychiatric conditions that have high heritability and high co-occurrence, such that at least one quarter of BD patients have BE (BD + BE). On the other hand, genetic studies of BD alone and of BE alone suggest complex polygenic risk models, with many genetic risk loci yet to be identifi...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
ConclusionsAvoidance coping and depressive symptoms emerged as key variables in understanding recent disordered eating among patients considering bariatric surgery. Pre-surgical psychological evaluations and treatment approaches could be enhanced with consideration of patient coping strategies, particularly avoidant coping responses to stress, independent of psychological distress.
Source: Obesity Surgery - Category: Surgery Source Type: research
This study aimed to identify demographic and clinical predictors of response to Tele-CBT among 79 patients who received Tele-CBT in three previous studies. List-wise deletion was applied after which n=58 patients were included in a multivariate linear regression adjusted for age, sex, and education status, to evaluate patient rurality index (urban or non-urban), and baseline binge eating (BES), emotional eating (EES), and depression symptoms (PHQ-9), as predictors of tele-CBT response. The predictors explained 31% of the observed variance (R2=.312, F (4,57) =3.238, p
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
CONCLUSIONS: Findings based on this nationally representative sample are that overvaluation was associated with greater functional impairment within BED, and BED+OV reported greater impairment than BN in interference with normal activities but less impairment related to mental health. The increased impairment associated with BED+OV provides support for overvaluation as a diagnostic specifier for BED. PMID: 31265763 [PubMed - as supplied by publisher]
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
AbstractPurpose of ReviewTo present current data on the coexistence of attention deficit hyperactivity disorder (ADHD) and the metabolic syndrome and type 2 diabetes mellitus in adults and children and to discuss possible mechanisms.Recent FindingsEmerging data suggest that risk factors for obesity and insulin resistance such as diabetes during pregnancy and intrauterine growth failure may also have a role in the development of ADHD. Furthermore, ADHD and obesity share lifestyle factors, such as abnormal eating patterns, binge eating, and a sedentary lifestyle. ADHD is a risk factor for components of the metabolic syndrome...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
Authors: Brugnera A, Carlucci S, Compare A, Tasca GA Abstract Interpersonal problems play a prominent role in the development of binge-eating disorder (BED), so that reducing their intensity may be a key focus of many psychological interventions. In recent years, several interpersonal treatments for BED were developed, which posit that binge-eating arises to manage relational problems. However, few studies have evaluated the prototypical interpersonal problems, and no studies evaluated the longitudinal changes in interpersonal functioning after treatment within this population. We investigated the severity and prot...
Source: Clinical Psychology and Psychotherapy - Category: Psychiatry Tags: Clin Psychol Psychother Source Type: research
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