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New Ebola outbreak rings alarm bells early

Source: ScienceNOW - Category: Science Authors: Tags: Epidemiology, Immunology, Pharmacology, Toxicology, Virology In Depth Source Type: news

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Filoviruses (family Filoviridae) include five ebolaviruses and Marburg virus. These pathogens cause a rapidly progressing and severe viral disease with high mortality rates (generally 30–90%). Outbreaks of filovirus disease are sporadic and, until recently, were limited to less than 500 cases. However, the 2013–2016 epidemic in western Africa, caused by Ebola virus (EBOV), illustrated the potential of filovirus outbreaks to escalate to a much larger scale (over 28,000 suspected cases). mAbs against the envelope glycoprotein represent a promising therapeutic platform for managing filovirus infections. However, m...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Protein Structure and Folding Source Type: research
Findings from a study done in 12 cynomolgus macaques suggest that common immune responses to Ebola virus could serve as an early marker for infection. The monkeys, which were infected intranasally with Ebola virus, presented with varying times to disease onset, but about 4 days before fever began in each one, researchers noticed a distinctive upregulation of interferon-stimulating genes. Comparison with data from the 2014 –16 Ebola outbreak in Guinea showed activation of the same genes, in the same order, in human beings.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Newsdesk Source Type: research
by Nicola De Maio, Colin J. Worby, Daniel J. Wilson, Nicole Stoesser Pathogen genome sequencing can reveal details of transmission histories and is a powerful tool in the fight against infectious disease. In particular, within-host pathogen genomic variants identified through heterozygous nucleotide base calls are a potential source of information to identify linke d cases and infer direction and time of transmission. However, using such data effectively to model disease transmission presents a number of challenges, including differentiating genuine variants from those observed due to sequencing error, as well as the spec...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
[EA Business] Johannesburg -The African Risk Capacity (ARC), an agency of the African Union, is developing an insurance product to facilitate rapid, first-line financial responses to disease outbreaks.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Humanities and social sciences have had many positive influences on health experiences, care, and expenditure. These include on self-management for diabetes, provision of psychological therapy, handwashing, hospital checklists, the Scottish Government's stroke guidelines, England's tobacco control strategy, the response to the Ebola outbreak in west Africa and Zika virus in Brazil, and many more.1 Researchers have shown time and time again the political, practical, economic, and civic value of education and research in disciplines like anthropology, history, and philosophy.
Source: LANCET - Category: General Medicine Authors: Tags: Comment Source Type: research
Publication date: Available online 17 March 2018 Source:Microbes and Infection Author(s): Sagar B. Kudchodkar, Hyeree Choi, Emma L. Reuschel, Rianne Esquivel, Jackie Jin-Ah Kwon, Moonsup Jeong, Joel N. Maslow, Charles C. Reed, Scott White, J. Joseph Kim, Gary P. Kobinger, Pablo Tebas, David B. Weiner, Kar Muthumani Vaccines are considered one of the greatest advances in modern medicine. The global burden of numerous infectious diseases has been significantly reduced, and in some cases, effectively eradicated through the deployment of specific vaccines. However, efforts to develop effective new vaccines against infectious ...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Abstract Global efforts to eradicate polio began in 1988, and four of the six World Health Organization (WHO) regions currently have achieved poliofree certification. Within the remaining two regions with endemic poliomyelitis (African and Eastern Mediterranean), Afghanistan, Nigeria, and Pakistan have never interrupted transmission of wild poliovirus (WPV). The primary means of detecting poliovirus transmission is surveillance for acute flaccid paralysis (AFP) among children aged
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
This study aimed to assess the effects of the outbreak on Prevent...
Source: Reproductive Health - Category: OBGYN Authors: Tags: Research Source Type: research
U.S. Agency for International Development. 04/01/2018 This three-part series of podcasts discusses how the recent outbreaks of Ebola and Zika demonstrate the need for new and improved tools to fight infectious diseases. Part One provides the context around current and future efforts in the prevention of and response to infectious disease outbreaks. Parts Two and Three detail how the U.S. Agency for International Development identifies and invests in the most promising ideas, and applies market-oriented approaches to reduce the time it takes to transform ideas in a lab to impact on the ground. (Video or Multimedia)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Authors: Source Type: news
Recent outbreaks of Ebola virus disease (2013-2016) and Zika virus (2015-2016) bring renewed recognition of the need to understand social pathways of disease transmission and barriers to care. Social scientists, anthropologists in particular, have been rec...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news
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