Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression
Genome-wide association studies (GWASs) have identified a multitude of genetic loci involved with traits and diseases. However, it is often unclear which genes are affected in such loci and whether the associated genetic variants lead to increased or decreased gene function. To mitigate this, we integrated associations of common genetic variants in 57 GWASs with 24 studies of expression quantitative trait loci (eQTLs) from a broad range of tissues by using a Mendelian randomization approach. We discovered a total of 3,484 instances of gene-trait-associated changes in expression at a false-discovery rate
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Mads Engel Hauberg, Wen Zhang, Claudia Giambartolomei, Oscar Franz én, David L. Morris, Timothy J. Vyse, Arno Ruusalepp, CommonMind Consortium, Pamela Sklar, Eric E. Schadt, Johan L.M. Björkegren, Panos Roussos Tags: Article Source Type: research