Continuous Flow Sterilization of Simple Biowaste Streams
PRI Bio's AutoFlow is designed for applications in biologics, virology, vaccine, genetically modified organism (GMO), and contract manufacturing organization (CMO) pilot plant research labs through large-scale manufacturing facilities.
Authors: Chen K, Wu Z, Zang M, Wang C, Wang Y, Wang D, Ma Y, Qu C Abstract BACKGROUND: Glypican-3 (GPC3) is one of the key tissue markers that could discriminate malignant precancerous lesions from benign hepatic lesions in cirrhotic patients. We aimed to develop a GPC3 cancer vaccine to induce specific T cells to intervene in hepatocellular carcinoma (HCC) development. METHODS: Synthesizing mannosylated liposomes (LPMan) as vaccine delivery system, incorporating one Toll-like receptor (TLR)-7/8 agonist CL097 as adjuvant, we prepared a GPC3 nanovaccine, LPMan-GPC3/CL097. We injected 25 mg/kg diethylnitrosamine ...
This study measured the zoster-associated burden in a Brazilian population. METHODS: This was a prospective, observational, single-cohort study conducted in a primary hospital ’ s emergency room in S ão Paulo, Brazil. Patients enrolled at various timepoints during a zoster episode were followed over 180 days. The Zoster Brief Pain Inventory and the Initial Zoster Impact Questionnaire assessed zoster-associated pain. The EuroQoL assessed the impact of herpes zoster and/or zoster-associated pain on quality of life. Healthcare resource utilization was assessed by patient-reported questionnaires. RESULTS: One-hund...
Abstract Sexual conflict is acknowledged as pervasive, with the potential to generate and maintain genetic variation. Mechanistic studies of conflict have been important in providing direct evidence for the existence of sexual conflict. They have also led to the growing realization that there is a striking phenotypic diversity of adaptations whose evolution can be shaped by sexually antagonistic selection. The mechanisms involved range from the use of genital spines, claspers, songs, and smells to ejaculate molecules. In one well-studied example, sexual conflict can occur over the sexually antagonistic effects of ...
Condition: Pancreatic Ductal Adenocarcinoma Intervention: Drug: mDC3/8-KRAS Vaccine Sponsor: University of Pennsylvania Not yet recruiting
Condition: Human Papillomavirus Vaccination Intervention: Behavioral: Educational workshop Sponsor: International Agency for Research on Cancer Enrolling by invitation
Condition: Inflammatory Bowel Diseases Intervention: Biological: SHINGRIX Sponsor: Boston Medical Center Not yet recruiting
Conditions: Monoclonal Gammopathy; Smoldering Myeloma; Myeloma Intervention: Biological: DKK1 Sponsor: Case Comprehensive Cancer Center Not yet recruiting
[Focac] Khartoum -Sudan's Ministry Health has launched a polio vaccination campaign targeting around 3 million children nationwide.
Funding to support research activities that will advance NIAIDs mission to develop a universal influenza vaccine providing durable protection against multiple influenza strains, including efforts to: 1) improve understanding of transmission, natural history and pathogenesis of influenza virus infection; 2) characterize influenza immunity and correlates of immune protection; and 3) support rational design of universal influenza vaccines.