Diffusion tensor imaging of cingulum bundle and corpus callosum in schizophrenia vs. bipolar disorder
Both schizophrenia and bipolar disorder show abnormalities of white matter, as seen in diffusion tensor imaging (DTI) analyses of major brain fibre bundles. While studies in each of the two conditions have indicated possible overlap in anatomical location, there are few direct comparisons between the disorders. Also, it is unclear whether phenotypically similar subgroups (e.g. patients with bipolar disorder and psychotic features) might share white matter pathologies or be rather similar. Using region-of-interest (ROI) analysis of white matter with diffusion tensor imaging (DTI) at 3 T, we analysed fractional anisotropy (FA), radial diffusivity (RD), and apparent diffusion coefficient (ADC) of the corpus callosum and cingulum bundle in 33 schizophrenia patients, 17 euthymic (previously psychotic) bipolar disorder patients, and 36 healthy controls.
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Igor Nenadic, Anna Hoof, Maren Dietzek, Kerstin Langbein, J ürgen R. Reichenbach, Heinrich Sauer, Daniel Güllmar Source Type: research