mTOR signaling in the differentiation and function of regulatory and effector T cells.

mTOR signaling in the differentiation and function of regulatory and effector T cells. Curr Opin Immunol. 2017 May 20;46:103-111 Authors: Zeng H, Chi H Abstract The mechanistic target of rapamycin (mTOR) signaling pathway integrates environmental signals and cellular metabolism to regulate T cell development, activation and differentiation. Recent studies reveal the importance of exquisite control of mTOR activity for proper T cell function, and detailed molecular mechanisms that regulate mTOR signaling in different T cell subsets. Here, we review the latest advances in our understanding of the mTOR pathway and its regulation in the differentiation and function of regulatory T cells and effector T cells. PMID: 28535458 [PubMed - as supplied by publisher]
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Tags: Curr Opin Immunol Source Type: research