ATP-induced Ca(2+)-signalling mechanisms in the regulation of mesenchymal stem cell migration.

ATP-induced Ca(2+)-signalling mechanisms in the regulation of mesenchymal stem cell migration. Cell Mol Life Sci. 2017 May 22;: Authors: Jiang LH, Mousawi F, Yang X, Roger S Abstract The ability of cells to migrate to the destined tissues or lesions is crucial for physiological processes from tissue morphogenesis, homeostasis and immune responses, and also for stem cell-based regenerative medicines. Cytosolic Ca(2+) is a primary second messenger in the control and regulation of a wide range of cell functions including cell migration. Extracellular ATP, together with the cognate receptors on the cell surface, ligand-gated ion channel P2X receptors and a subset of G-protein-coupled P2Y receptors, represents common autocrine and/or paracrine Ca(2+) signalling mechanisms. The P2X receptor ion channels mediate extracellular Ca(2+) influx, whereas stimulation of the P2Y receptors triggers intracellular Ca(2+) release from the endoplasmic reticulum (ER), and activation of both type of receptors thus can elevate the cytosolic Ca(2+) concentration ([Ca(2+)]c), albeit with different kinetics and capacity. Reduction in the ER Ca(2+) level following the P2Y receptor activation can further induce store-operated Ca(2+) entry as a distinct Ca(2+) influx pathway that contributes in ATP-induced increase in the [Ca(2+)]c. Mesenchymal stem cells (MSC) are a group of multipotent stem cells that grow from adult tissues and hold promising applications in ...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research