[Correspondence] Defining sepsis: inspiring proposals meet practical realities

The Article1 by John P Donnelly and colleagues compared sepsis incidence and mortality among patients identified by systemic inflammatory response syndrome (SIRS) criteria, and the sepsis-related organ failure assessment (SOFA) and quick SOFA (qSOFA) classifications presented by Sepsis-3.2 Their study confirmed that SOFA and qSOFA are more effective at identifying patients at elevated risk of poor outcomes than is SIRS. However, as the authors observe, the operational roles of SOFA and qSOFA at the time of initial presentation is not clear: SOFA is not designed for acute management triage and qSOFA has yet to undergo large-scale prospective validation.

Source: The Lancet Infectious Diseases - May 24, 2017 Category: Infectious Diseases Authors: Melinda Munang, Saleem Chaudhri, Methini Himayakanthan, Steven Laird, Amy Moltu, Natasha Naworynsky, Christopher Pollard, Tahir Saeed, Paul Scott, Cathleen Chan, Maya Sussman, Shaun Thein, George Trafford, Ariyur Balaji, Neil Jenkins, Ed Moran Tags: Correspondence Source Type: research