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Mucin- and carbohydrate-stimulated adhesion and subproteome changes of the probiotic bacterium Lactobacillus acidophilus NCFM.

Mucin- and carbohydrate-stimulated adhesion and subproteome changes of the probiotic bacterium Lactobacillus acidophilus NCFM. J Proteomics. 2017 May 19;: Authors: Celebioglu HU, Olesen SV, Prehn K, Lahtinen SJ, Brix S, Hachem MA, Svensson B Abstract Adhesion to intestinal mucosa is a crucial property for probiotic bacteria. Adhesion is thought to increase host-bacterial interactions, thus potentially enabling health benefits to the host. Molecular events connected with adhesion and surface proteome changes were investigated for the probiotic Lactobacillus acidophilus NCFM cultured with established or emerging prebiotic carbohydrates as carbon source and in the presence of mucin, the glycoprotein of the epithelial mucus layer. Variation in adhesion to HT29-cells and mucin was associated with carbon source and mucin-induced subproteome abundancy differences. Specifically, while growth on fructooligosaccharides (FOS) only stimulated adhesion to intestinal HT-29 cells, cellobiose and polydextrose in addition increased adhesion to mucin. Adhesion to HT-29 cells increased by about 2-fold for bacteria grown on mucin-supplemented glucose. Comparative 2DE-MS surface proteome analysis showed different proteins in energy metabolism appearing on the surface, suggesting they exert moonlighting functions. Mucin-supplemented bacteria had relative abundance of pyruvate kinase and fructose-bisphosphate aldolase increased by about 2-fold while six spots with 3.2-2.1 fold...
Source: Journal of Proteomics - Category: Biochemistry Authors: Tags: J Proteomics Source Type: research

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Source: Resuscitation - Category: Emergency Medicine Source Type: research
Source: Resuscitation - Category: Emergency Medicine Source Type: research
We would like to thank Drs. Lapostolle, Lecomte, Arnaudet, Javaudin, Pes, and Petrovic for their thoughtful comments regarding our paper “Ultrasound use during cardiopulmonary resuscitation is associated with delays in chest compressions.” They raise several important points regarding the paper that warrant clarification.
Source: Resuscitation - Category: Emergency Medicine Authors: Tags: Letter to the Editor Source Type: research
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Source: Resuscitation - Category: Emergency Medicine Authors: Tags: Letter to the Editor Source Type: research
Authors: Korkmaz A, Sahin D, Guray U Abstract AIM: Recently fragmented QRS (fQRS) on ECG has been introduced as a predictor of myocardial scarring and myocardial ischemia in coronary artery disease. OBJECTIVE: The aim of this study was to investigate the relationship between fQRS and fractional flow reserve (FFR) results in patients with the intermediate degree of coronary artery stenosis. METHODS: A total of 301 consecutive patients who underwent coronary angiography and FFR measurement for intermediate coronary artery stenosis were included in the study. The study patients were divided into two ...
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
CONCLUSION: The expression of Bmi-1 is associated with the progression and invasion of esophageal cancer. PMID: 29240461 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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