Validity of the Rheumatoid Arthritis Impact of Disease (RAID) score and definition of cut-off points for disease activity states in a population-based European cohort of patients with rheumatoid arthritis

Conclusions The cut-offs revealed good measurement characteristics in cross-validation analyses, had great discriminatory performance in distinguishing patients with different levels of disease activity and are suited for widespread use in everyday practice application and research.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research

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Authors: Ge Y, Chen S, Luo Q, Wang CP, Hao J, He J, Chen X, Yang X, Li J, Chang YX Abstract Angelicae pubescentis radix (APR) is widely applied in treating rheumatoid arthritis in China. Coumarins are the major active compounds of APR extract including columbianetin, columbianetin acetate, osthole, and columbianadin. The in vivo behavior of the four major coumarins of APR has not been systematically reported. A feasible and reliable ultra-performance liquid chromatography (UPLC) method was established and validated for the quantification of the above four coumarins in rat various tissues (including heart, liver, sp...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
ConclusionThere was no significant association between the patterns of electronic devices use and CTS symptoms. The high prevalence of CTS symptoms necessitates awareness programs, especially among the young population. Although this work did not prove the association, further studies with confirmatory clinical testing are recommended.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
Conclusions: The primary goal of pharmacodynamic monitoring is to optimize the response, but it can also have an impact on safety, costs, patient adherence, etc. Ideally, the constant remote monitoring of patient-reported disease activity is expected to become the standard, facilitated by mHealth technologies.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Review Articles: Focus on Pharmacodynamic Drug Monitoring Source Type: research
This article aims to and describes the characteristics of rheumatology practice in Japan, focusing on the medical environment for the treatment of rheumatoid arthritis (RA). In Japan, the introduction of biological disease-modifying anti-rheumatic drugs (bDMARDs) has led to a significant paradigm shift in medical care; satisfactory safety outcomes have been demonstrated by periodic analysis, post-market surveillance and the development of guidelines via an industry –academia–government collaboration. Drug discontinuation is also considered an option, as well as medical economic analysis of any increase in the f...
Source: Rheumatology International - Category: Rheumatology Source Type: research
ConclusionThe combination of a PD assessment or the cPD score with the measurement of autoantibodies of rheumatoid factor and/or anti ‐cyclic citrullinated peptide antibodies can accurately identify patients with early‐stage RA.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractEmerging data revealed that rheumatoid arthritis (RA) is associated with higher risk of cerebrovascular diseases. Whereas cerebral endothelial dysfunction is acknowledged as a critical aspect of cerebrovascular diseases, its presence in RA and the mechanisms involved are currently unknown. By using the model of rat adjuvant-induced arthritis (AIA), the present study investigated cerebrovascular reactivity in pressurized middle cerebral arteries (MCA) on day 33 post-immunization. The results revealed that arthritis induced a dramatic decrease in the vasodilatory response to acetylcholine (ACh), ADP, and bradykinin (...
Source: Translational Stroke Research - Category: Neurology Source Type: research
AbstractIn suspected and diagnosed rheumatoid arthritis (RA), magnetic resonance imaging (MRI) allows detection of all relevant pathologies, such as synovitis, tenosynovitis, bone marrow edema (osteitis), bone erosion and cartilage damage. MRI is more sensitive than clinical examination for monitoring disease activity (i.e., inflammation) and more sensitive than conventional radiography and ultrasonography for monitoring joint destruction. In suspected RA, MRI bone marrow edema predicts development of RA, and in early RA patients, it predicts subsequent structural damage progression. CT is the standard reference imaging mo...
Source: La Radiologia Medica - Category: Radiology Source Type: research
AbstractBackground/PurposeRheumatoid arthritis (RA) patients with the lowest circulating low ‐density lipoprotein concentrations (LDL‐C) are at heightened risk for cardiovascular disease (CVD) events. However, atherosclerotic burden within this subgroup is unknown.MethodsRA patients pooled from 4 cohort studies of CVD (n=546) were compared with non ‐RA controls from the Multi‐Ethnic Study of Atherosclerosis (MESA; n=5,279). Those on lipid lowering medications were excluded. Differences in cardiac computed tomography‐derived coronary arterial calcium (CAC) Agatston scores between the RA and control groups were com...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
AbstractA physiologically based pharmacokinetic (PBPK) model was used to simulate the impact of elevated levels of interleukin (IL)-6 on the exposure of several orally administered cytochrome P450 (CYP) probe substrates (caffeine, S-warfarin, omeprazole, dextromethorphan, midazolam, and simvastatin). The changes in exposure of these substrates in subjects with rheumatoid arthritis (and hence elevated IL-6 levels) compared with healthy subjects were predicted with a reasonable degree of accuracy. The PBPK model was then used to simulate the change in oral exposure of the probe substrates in North European Caucasian, Chinese...
Source: The AAPS Journal - Category: Drugs & Pharmacology Source Type: research
No abstract available
Source: Lippincott's Bone and Joint Newsletter - Category: Orthopaedics Tags: Perspective Source Type: news
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