Within-host selection of drug resistance in a mouse model of repeated interrupted treatment of Plasmodium yoelii infection

To study within-host selection of resistant parasites, an important factor in the development of resistance to anti-malarial drugs, a mouse model of repeated interrupted malaria treatment (RIT) has been develo...
Source: Malaria Journal - Category: Infectious Diseases Authors: Source Type: research

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by Angela Nalwoga, Emily L. Webb, Belinda Chihota, Wendell Miley, Bridgious Walusimbi, Jacent Nassuuna, Richard E. Sanya, Gyaviira Nkurunungi, Nazzarena Labo, Alison M. Elliott, Stephen Cose, Denise Whitby, Robert Newton We investigated the impact of helminths and malaria infection on Kaposi’s sarcoma associated herpesvirus (KSHV) seropositivity, using samples and data collected from a cluster-randomised trial of intensive versus standard anthelminthic treatment. The trial was carried out in 2012 to 2016 among f ishing communities on Lake Victoria islands in Uganda. Plasma samples from 2881 participants from two hou...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
A gene enabled the malaria parasite to infect both gorillas and humans for a limited time, explaining how the jump was made at a molecular level, researchers say.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news
Discovery of mutation 50,000 years ago could help in the fight against malaria.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Scientists who resurrected a 50,000-year-old gene sequence have analyzed it to figure out how the world's deadliest malaria parasite jumped from gorillas to humans - giving insight into the origins of one of human history's biggest killers.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Contributors : Wieteke A Hoeijmakers ; Rich árd Bártfai ; Christa G ToenhakeSeries Type : Expression profiling by high throughput sequencingOrganism : Plasmodium falciparumEpigenetic regulatory mechanisms are central to the development and survival of all eukaryotic organisms. These mechanisms critically depend on the marking of chromatin domains with distinctive histone tail modifications (PTMs) and their recognition by effector protein complexes. In this project, histone peptide pull-downs and protein-protein interaction quantitative proteomics were used to unveil interactions between PTMs and associated re...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Plasmodium falciparum Source Type: research
Date: Wednesday, 11 13, 2019; Speaker: Laura Amo, Ph.D. , Postdoctoral Fellow, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases; Building: Building 45 (Natcher Building); Ruth Kirschstein Auditorium
Source: NIH Calendar of Events - Category: American Health Source Type: events
This study was designed to determine the prevalence of malaria parasite recurrence and hematological alterat...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research article Source Type: research
We reported three cases of possible parasite resistance to artemether-lumefantrine therapy. All subjects had complete parasite clearance when treated with other antimalarial drugs. This observation necessitates the urgent need to re-evaluate artemether-lumefantrine medication in Nigeria since it is one of the most commonly used ACT drug.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
by Francis Galaway, Ryan Yu, Anastasia Constantinou, Franck Prugnolle, Gavin J. Wright Many important infectious diseases are the result of zoonoses, in which pathogens that normally infect animals acquire mutations that enable the breaching of species barriers to permit the infection of humans. Our understanding of the molecular events that enable host switching are often limited, and yet this is a fundamentally important question.Plasmodium falciparum, the etiological agent of severe human malaria, evolved following a zoonotic transfer of parasites from gorillas. One gene —rh5—which encodes an essential liga...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
Malaria is still a significant public health burden in the tropics. Infection with malaria causing parasites results in a wide range of clinical disease presentations, from severe to uncomplicated or mild, and in the poorly understood asymptomatic infections. The complexity of asymptomatic infections is due to the intricate interplay between factors derived from the human host, parasite, and environment. Asymptomatic infections often go undetected and provide a silent natural reservoir that sustains malaria transmission. This creates a major obstacle for malaria control and elimination efforts. Numerous studies have tried ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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