Concepts of Genomics in Kidney Transplantation

AbstractPurpose of ReviewIdentification of genetic variants to aid in individualized treatment of solid organ allograft recipients would improve graft survival. We will review the current state of knowledge for associations of variants with transplant outcomes.Recent FindingsMany studies have yet to exhibit robust and reproducible results; however, pharmacogenomic studies focusing on cytochrome P450 (CYP) enzymes, transporters, and HLA variants have shown strong associations with outcomes and have relevance towards drugs used in transplant. Genome wide association study data for the immunosuppressant tacrolimus have identified multiple variants in theCYP3A5 gene associated with trough concentrations. Additionally,APOL1 variants had been shown to confer risk to the development of end stage renal disease in African Americans.SummaryThe field is rapidly evolving and new technology such as next-generation sequencing, along with larger cohorts, will soon be commonly applied in transplantation to understand genetic association with outcomes and personalized medicine.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research