Clinical Correlates, Ethnic Differences, and Prognostic Implications of Perivascular Spaces in Transient Ischemic Attack and Ischemic Stroke [Clinical Sciences]

Background and Purpose—Perivascular spaces (PVSs) are considered markers of small vessel disease. However, their long-term prognostic implications in transient ischemic attack/ischemic stroke patients are unknown. Ethnic differences in PVS prevalence are also unknown.Methods—Two independent prospective studies were conducted, 1 comprising predominantly whites with transient ischemic attack/ischemic stroke (OXVASC [Oxford Vascular] study) and 1 comprising predominantly Chinese with ischemic stroke (University of Hong Kong). Clinical and imaging correlates, prognostic implications for stroke and death, and ethnic differences in basal ganglia (BG) and centrum semiovale (CS) PVSs were studied with adjustment for age, sex, vascular risk factors, and scanner strength.Results—Whites with transient ischemic attack/ischemic stroke (n=1028) had a higher prevalence of both BG and CS-PVSs compared with Chinese (n=974; >20 BG-PVSs: 22.4% versus 7.1%; >20 CS-PVSs: 45.8% versus 10.4%; P

Source: Stroke - May 22, 2017 Category: Neurology Authors: Kui–Kai Lau, Linxin Li, Caroline E. Lovelock, Giovanna Zamboni, Tsz–Tai Chan, Man–Fung Chiang, Kin–Ting Lo, Wilhelm Kuker, Henry Ka–Fung Mak, Peter M. Rothwell Tags: Imaging, Magnetic Resonance Imaging (MRI), Prognosis, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research