Myeloid differentiation factor 88 is up-regulated in epileptic brain and contributes to experimental seizures in rats.

Myeloid differentiation factor 88 is up-regulated in epileptic brain and contributes to experimental seizures in rats. Exp Neurol. 2017 May 18;: Authors: Wang N, Han X, Liu H, Zhao T, Li J, Feng Y, Mi X, Zhang Y, Chen Y, Wang X Abstract Accumulating evidence supports that activation of inflammatory pathways is a crucial factor contributing to the pathogenesis of seizures. In particular, the activation of interleukin-1 beta (IL-1β) system exerts proconvulsant effects in a large variety of seizure models. Myeloid differentiation factor 88 (MyD88) is a critical adaptor protein in the signaling cascade elicited by IL-1β. The present study aimed to investigate the expression pattern of MyD88 in rat models of seizures and in patients with refractory temporal lobe epilepsy (TLE), and to study the role of MyD88 in epileptic seizures. Our results revealed that MyD88 was up-regulated in the hippocampus of rats in the lithium-pilocarpine model of acute seizures. Importantly, MyD88 overexpression was also significantly present in the brain from chronic epileptic rats and the temporal neocortex specimens from drug-resistant TLE patients. In the acute seizure model, both the behavioral and electrographic seizure activities were record and analyzed in rats for 90min, starting immediately after pilocarpine injection. ST2825, a synthetic MyD88 inhibitor, was administered intracerebroventricularly (2.5-5.0-10μg in 2μl) 20min before pilocarpine injection. W...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

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ConclusionThis review confirms that healthcare professionals should discus SUDEP with CYPwE and/or their caregivers at or around the time of diagnosis and that the discussion should include prevalence of SUDEP, risk factors and risk reduction methods relative to the individual concerned. Apart from delivering SUDEP information face-to-face, with written or online information provided to reinforce messages, there is a lack of evidence on “how” to impart this sensitive information. Further research exploring the most acceptable and effective methods of discussing SUDEP with CYPwE and their caregivers is therefore indicated.
Source: Seizure - Category: Neurology Source Type: research
ConclusionsThe findings of this study demonstrate that the proposed prediction strategy is suitable for the prediction of seizure onset.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Authors: Scheffer IE, Liao J Abstract [Box: see text]. PMID: 31601119 [PubMed - as supplied by publisher]
Source: Epilepsy Currents - Category: Neurology Tags: Epilepsy Curr Source Type: research
Publication date: December 2019Source: Molecular Genetics and Metabolism Reports, Volume 21Author(s): Remi Stevelink, Faith Pangilinan, Floor E. Jansen, Kees P.J. Braun, International League Against Epilepsy Consortium on Complex Epilepsies, Anne M. Molloy, Lawrence C. Brody, Bobby P.C. KoelemanAbstractAltered vitamin B6 metabolism due to pathogenic variants in the gene PNPO causes early onset epileptic encephalopathy, which can be treated with high doses of vitamin B6. We recently reported that single nucleotide polymorphisms (SNPs) that influence PNPO expression in the brain are associated with genetic generalized epilep...
Source: Molecular Genetics and Metabolism Reports - Category: Genetics & Stem Cells Source Type: research
In this report, we present a case of UFS, not due to HFS, highlighting clinical red flags for an alternative diagnosis.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
Sudden unexplained death in epilepsy (SUDEP) is commonly defined as “sudden, unexpected, witnessed or unwitnessed, nontraumatic and nondrowning death in patients with epilepsy, with or without evidence for a seizure and excluding documented status epilepticus, in which post-mortem examination does not reveal a toxicologic or anatomic cause for death” [1]. Due to difficulties with definitive diagnosis it is increasingly classified as definite, probable or possible [1]. Epilepsy is a common neurological disease in children, and whilst SUDEP is considered a relatively rare event, it has a devastating effect on fam...
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
Purpose of review Although ketogenic diet therapies (KDTs) were first developed as a treatment for patients with epilepsy, their potential efficacy for a broader number of neurologic and nonneurologic disorders and conditions has been explored over the last 10–20 years. The most recent clinical trials of KDTs in adults have highlighted common methodological aspects that can either facilitate or thwart appropriate risk/benefit analyses, comparisons across studies, and reproducibility of findings in future studies. Recent findings Recent evidence suggests that KDTs not only improve seizure control, but also improv...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: NUTRITION AND PHYSIOLOGICAL FUNCTION: Edited by Labros S. Sidossis and Annemie M.W. Schols Source Type: research
Decreased in BEN was associated with the intrinsic alertness RT and phasic alertness in patients with rTLE. The abnormal FC in brain regions with altered entropy suggests reconstruction of brain functional connectivity. AbstractBackgroundTo date, no functional MRI (fMRI) studies have focused on brain entropy in right temporal lobe epilepsy (rTLE) patients. Here, we characterized brain entropy (BEN) alterations in patients with rTLE using resting ‐state functional MRI(rs‐fMRI) and explored the relationship between BEN and alertness.MethodThirty ‐one rTLE patients and 33 controls underwent MRI scanning to investigate d...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Howlett Cannabinoid receptor interacting protein 1a (CRIP1a) is an important CB1 cannabinoid receptor-associated protein, first identified from a yeast two-hybrid screen to modulate CB1-mediated N-type Ca2+ currents. In this paper we review studies of CRIP1a function and structure based upon in vitro experiments and computational chemistry, which elucidate the specific mechanisms for the interaction of CRIP1a with CB1 receptors. N18TG2 neuronal cells overexpressing or silencing CRIP1a highlighted the ability of CRIP1 to regulate cyclic adenosine 3′,5′monophosphate (cAMP) production and extracellular...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Authors: Velez-Ruiz N Abstract [Box: see text]. PMID: 31597457 [PubMed - as supplied by publisher]
Source: Epilepsy Currents - Category: Neurology Tags: Epilepsy Curr Source Type: research
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