Mesothelioma Study Using Fitbit to Monitor Patient Recovery

Millions of Americans use Fitbit devices to track their daily activities, exercise and sleep patterns. But a student intern at the Pacific Heart, Lung &Blood Institute (PHLBI) in California is using the popular fitness tracker for a different purpose — as a tool to measure postsurgery recovery for mesothelioma patients. Blair Kimble, a third-year undergraduate student at UCLA, is leading the latest clinical research project for the Pacific Mesothelioma Center (PCM), a division of PHLBI. Kimble is working closely with mesothelioma surgeon Dr. Robert Cameron, the scientific advisor at PHLBI. The study investigates some of first quantitative measures of postoperative mesothelioma patient recovery using Fitbit wristbands to collect data about a patient’s walking habits, heart rate and sleep patterns before and after surgery. “Using their data from before surgery as a baseline for their activity, we are then able to track how quickly they return to that normal baseline after surgery,” Kimble wrote in a PHLBI blog post explaining the study. The overall goal of the project is to use the Fitbit devices to motivate patients to return to presurgery physical activity levels, according to Dr. Raymond Wong, PHLBI lead researcher and head of the intern program. “This could ultimately result in shorter hospital stays on average and the use of Fitbit trackers as standard postsurgery monitoring,” Wong told Asbestos.com. Patient Recovery Is Under I...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Blair Kimble cancer immunotherapy research cryotherapy Dr. Raymond Wong Dr. Robert Cameron Dr. Steven Ching extrapleural pneumonectomy fitbit fitbit cancer recovery heated intraperitoneal chemotherapy Loyola Marymount University meso Source Type: news

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CONCLUSIONS: For peripheral lung cancer, the measurement on CT and routine MRI sequences can potentially replace each other after comprehensive consideration of examination purposes, but for central lung cancer, alternative use of CT and MRI in evaluating treatment responses for lung cancer should needs extra attention. The diameter measurement of lung cancer on DWI is consistent with that on T1WI and T2WI, suggesting that DWI can provide functional and morphological information. PMID: 32083610 [PubMed - as supplied by publisher]
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research
Authors: Visochek L, Atias D, Spektor I, Castiel A, Golan T, Cohen-Armon M Abstract [This corrects the article DOI: 10.18632/oncotarget.27268.]. PMID: 32082490 [PubMed - in process]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Lopez S, Perrone E, Bellone S, Bonazzoli E, Zeybek B, Han C, Tymon-Rosario J, Altwerger G, Menderes G, Bianchi A, Zammataro L, Manzano A, Manara P, Ratner E, Silasi DA, Huang GS, Azodi M, Schwartz PE, Raspagliesi F, Angioli R, Buza N, Hui P, Bond HM, Santin AD Abstract Background: Uterine and ovarian carcinosarcomas (CS) are rare cancers with poor prognosis. Sacituzumab-govitecan (SG) is a new class of antibody-drug-conjugate (ADC) targeting the human-trophoblast-cell-surface marker (Trop-2) conjugated with the active metabolite of irinotecan (SN-38). We evaluated the efficacy of SG against biologically ag...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusions: Niche mutations exhibited an increased risk of death when compared with EGFR mutations and a similar risk of death when compared with KRAS mutations. PMID: 32082488 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In this study, we evaluated the effect of FDA-approved kinase inhibitors on GC. Through a combination of cell growth, migration and invasion assays, we identified dasatinib as an efficient inhibitor of GC proliferation. Mass-spectrometry-based selectivity profiling and subsequent knockdown experiments identified members of the SRC family of kinases including SRC, FRK, LYN and YES, as well as other kinases such as DDR1, ABL2, SIK2, RIPK2, EPHA2, and EPHB2 as dasatinib targets. The expression levels of the identified kinases were investigated on RNA and protein level in 200 classified tumor samples from patients, who had und...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Jabalee J, Towle R, Lawson J, Dickman C, Garnis C Abstract Neutral sphingomyelinase 2 (nSMase2), the product of the sphingomyelin phosphodiesterase 3 (SMPD3) gene, catalyzes the hydrolysis of sphingomyelin to ceramide. Ceramide acts on various signaling pathways to influence cell proliferation, survival, and stress response. Altered levels of sphingolipids and ceramides have been reported in various cancer types, including oral squamous cell carcinoma (OSCC). OSCC patients exhibit a poor 5-year survival rate of 50%, a figure that has remained stagnant for decades. To overcome this requires a better underst...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Charan M, Dravid P, Cam M, Setty B, Roberts RD, Houghton PJ, Cam H Abstract The pre-metastatic niche (PMN) represents an abnormal microenvironment devoid of cancer cells, but favoring tumor growth. Little is known about the mechanisms that generate the PMN or their effects on host cells within metastasis-prone organs. Here, we investigated by using spontaneous metastatic models whether lung epithelial cells are essential for primary tumor induced neutrophil recruitment in lung and subsequently initiating PMN formation in osteosarcoma. We found that serum levels of ANGPTL2 in osteosarcoma patients are signi...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Correction: Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation. Oncotarget. 2020 Jan 21;11(3):304 Authors: Yan Y, Hein AL, Etekpo A, Burchett KM, Lin C, Enke CA, Batra SK, Cowan KH, Ouellette MM Abstract [This corrects the article DOI: 10.18632/oncotarget.2500.]. PMID: 32076492 [PubMed - in process]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Zhang J, He P, Xi Y, Geng M, Chen Y, Ding J Abstract [This corrects the article DOI: 10.18632/oncotarget.2784.]. PMID: 32076491 [PubMed - in process]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
We describe below a patient who has shown a response to combination of chemotherapy with Elenagen, a plasmid encoding p62. Elenagen was tested in a previous phase I/II study in patients with refractory solid tumors and shown to be safe. Also, plasmid ability to halt tumor progression and restore sensitivity to chemotherapy was found. Preclinical data supports effects on tumor grade and change the tumor's microenvironment in spontaneous canine breast cancers. We describe here a 48-year old female with triple-negative and BRCA1/2-negative breast cancer who had a primary resistance to chemotherapy and negative dynamics despit...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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