Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis

Conclusion NLRP3 inflammasomes were activated in podocytes of both LN patients and in lupus‐prone mice. Activation of NLRP3 is involved in the pathogenesis of podocyte injuries and the development of proteinuria in LN. This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fart.40155

Source: Arthritis and Rheumatism - May 23, 2017 Category: Rheumatology Authors: Rong Fu, Chaohuan Guo, Shuang Wang, Yuefang Huang, Ou Jin, Haoqiang Hu, Jingxian Chen, Bihua Xu, Mianjing Zhou, Jijun Zhao, Sun ‐sang J. Sung, Hongyang Wang, Felicia Gaskin, Niansheng Yang, Shu‐Man Fu Tags: Full Length Source Type: research