Annals of Neurology: Volume 81, Number 5, May 2017

ON THE COVER: An electron photomicrograph of an oligodendrocyte (dark cell in the middle) in a rat with a mutation in TUBB4A, which encodes β‐tubulin. These rats show accumulation of microtubules throughout the cytoplasm as well as arrays along the endoplasmic reticulum of oligodendrocytes, as can be seen in the cytoplasm ringing the nucleus of this cell. The oligodendrocyte is surrounded by hypomyelinated and demyelinated axons, which are also seen in many patients with mutations in TUBB4A. See Duncan et al, pp. 690–702, this issue.

Source: Annals of Neurology - May 23, 2017 Category: Neurology Tags: Cover Image Source Type: research