In oesophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-{kappa}B and activator protein-1

Conclusions
In oesophageal squamous epithelial cells, omeprazole inhibits IL-8 expression through effects on NF-B and AP-1 that are entirely independent of effects on gastric acid secretion. These previously unrecognised PPI effects might contribute to the healing of reflux oesophagitis.

Source: Gut - June 6, 2014 Category: Gastroenterology Authors: Huo, X., Zhang, X., Yu, C., Zhang, Q., Cheng, E., Wang, D. H., Pham, T. H., Spechler, S. J., Souza, R. F. Tags: Gastro-oesophageal reflux Oesophagus Source Type: research