Roles of Retinoic Acid in Germ Cell Differentiation.

Roles of Retinoic Acid in Germ Cell Differentiation.
Curr Top Dev Biol. 2017;125:191-225
Authors: Teletin M, Vernet N, Ghyselinck NB, Mark M
Abstract
The modalities of gametogenesis differ markedly between sexes. Female are born with a definitive reserve of oocytes whose size is crucial to ensure fertility. Male fertility, in contrast, relies on a tightly regulated balance between germ cell self-renewal and differentiation, which operates throughout life, according to recurring spatial and temporal patterns. Genetic and pharmacological studies conducted in the mouse and discussed in this review have revealed that all-trans retinoic acid and its nuclear receptors are major players of gametogenesis and are instrumental to fertility in both sexes.
PMID: 28527572 [PubMed - in process]

Source: Current Topics in Developmental Biology - May 23, 2017 Category: Biology Authors: Teletin M, Vernet N, Ghyselinck NB, Mark M Tags: Curr Top Dev Biol Source Type: research