The Function and Evolution of Nuclear Receptors in Insect Embryonic Development.
The Function and Evolution of Nuclear Receptors in Insect Embryonic Development. Curr Top Dev Biol. 2017;125:39-70 Authors: Cheatle Jarvela AM, Pick L Abstract Nuclear receptors are a family of transcription factors that are often responsive to small ligands, allowing for efficient gene expression-level responses to a stimulus. The average insect has 21 genes encoding nuclear receptors, whose functions are especially well studied in developmental transitions during the insect life cycle, such as metamorphosis and molting. However, their utility as well-controlled transcriptional regulators also lends them to important roles in embryogenesis, neurogenesis, metabolism, and organogenesis. Such developmental functions have been explored in depth in the model organism Drosophila melanogaster. More recently, advances in genomic resources and functional genomic methodologies have allowed for comparison of nuclear receptor function among a wider range of insect species. As has been the trend throughout the field of Evo-Devo, these new data sets reveal that many genes are shared, but the ways in which they are utilized in different lineages are more variable. In this chapter, we describe the suite of nuclear receptor genes found in Drosophila and their developmental functions. We then compare and contrast these genes and their functions in diverse insects. PMID: 28527580 [PubMed - in process]
CONCLUSION: The remains in the LTB tomb were not a traditional nuclear family (father, mother and son/daughter) and it was probably a tomb where two women, one of them pregnant, were buried. PMID: 30027753 [PubMed - as supplied by publisher]
Authors: Liew M, Rowe LR, Szankasi P, Paxton CN, Kelley T, Toydemir RM, Salama ME PMID: 30027711 [PubMed - in process]
Authors: Kim YJ, Ko JM, Song J, Lee KA PMID: 30027710 [PubMed - in process]
Authors: Oh J, Yoo IY, Song DJ, Lee JW, Kim YJ, Ki CS, Lee NY, Huh HJ PMID: 30027709 [PubMed - in process]
Authors: Sebastian S, Malhotra R, Sreenivas V, Kapil A, Chaudhry R, Dhawan B PMID: 30027708 [PubMed - in process]
Authors: Kim JH, Lee E, Lee Y PMID: 30027707 [PubMed - in process]
Authors: Heo ST, Kwon KT, Yoo JR, Choi JY, Lee KH, Ko KS PMID: 30027706 [PubMed - in process]
Authors: Shin KH, Lee HJ, Kim HH, Hong YJ, Park KU, Kim MJ, Kwon JR, Choi YS, Kim JN Abstract Frequencies of red blood cell (RBC) blood group antigens differ by ethnicity. Since the number of immigrants is increasing in Korea, RBC antigens should be assessed in children/youths with parents of different ethnicities to ensure safe transfusions. We investigated the frequency of RBC antigens, except for ABO and RhD, in 382 children and youths with parents having Korean and non-Korean ethnicities. Subjects were divided into those with ethnically Korean parents (Korean group; N=252) and those with at least one parent of ...
CONCLUSIONS: rs3761549, rs5902434, and rs2232365 are associated with an increased risk of acute GVHD and decreased risk of post-HSCT infection. PMID: 30027704 [PubMed - in process]
CONCLUSIONS: Our algorithm omitting weak D testing in D- patients with C-E- phenotype may be a cost-effective testing strategy in Korea. PMID: 30027703 [PubMed - in process]