Scientists develop test to identify best treatment for gonorrhea

FINDINGSResearchers from UCLA have developed a laboratory test that helps physicians determine which people with gonorrhea may be more treatable with an antibiotic that has not been recommended since 2007 because of concerns that the resistance to the drug was growing.BACKGROUNDGonorrhea has developed increasing resistance to all current antibiotics. Due to the spread of multi-drug resistant gonorrhea, health authorities have declared it one of the top-three urgent threats to public health.Ciprofloxacin was used to combat the sexually transmitted infection until 2007, when the Centers for Disease Control and Prevention stopped recommending its use after gonococcal infections developed resistance to it. Nevertheless, about 80 percent of gonorrhea infections in the United States, however, could be treated with ciprofloxacin. Scientists have been trying to determine how to better identify cases for targeted use of ciprofloxacin therapy, reducing the need to use the antibiotic ceftriaxone and risking increased resistance to that drug. Gonorrhea ’s resistance rate to ceftriaxone is currently less than 1 percent.METHODThe research was conducted at UCLA Health ’s hospitals, emergency departments and primary care clinics. After developing a test to detect a genetic change in gonorrhea that makes it resistant to ciprofloxacin, the researchers noted what treatments UCLA physicians had been using to treat gonorrhea. They then used the new test for all gonor rhea cases over a nine-mo...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news