Engineering genetically-encoded tools for optogenetic control of protein activity.

Engineering genetically-encoded tools for optogenetic control of protein activity.
Curr Opin Chem Biol. 2017 May 17;40:17-23
Authors: Liu Q, Tucker CL
Abstract
Optogenetic tools offer fast and reversible control of protein activity with subcellular spatial precision. In the past few years, remarkable progress has been made in engineering photoactivatable systems regulating the activity of cellular proteins. In this review, we discuss general strategies in designing and optimizing such optogenetic tools and highlight recent advances in the field, with specific focus on applications regulating protein catalytic activity.
PMID: 28527343 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - May 17, 2017 Category: Biochemistry Authors: Liu Q, Tucker CL Tags: Curr Opin Chem Biol Source Type: research