Can omega-3 help prevent Alzheimer's disease? Brain SPECT imaging shows possible link

The incidence of Alzheimer's disease is expected to triple in the coming decades and no cure has been found. Recently, interest in dietary approaches for prevention of cognitive decline has increased. In particular, the omega-3 fatty acids have shown anti-amyloid, anti-tau and anti-inflammatory actions in the brains of animals.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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This study investigated whether the clinical read of FPCIT SPECT predicts the patient’s survival. Patients from our clinical registry were included if they received an FPCIT SPECT between 10/2008 and 06/2016 and if their vital status (date of death, if applicable) could be determined in 07/2017. Cox proportional hazard models adjusted for age and sex were computed in order to test whether clinical reads of FPCIT scans (normal vs. pathological) predict survival. Analyses were stratified by indication for scanning (leading symptom: parkinsonism vs dementia). Vital status could be determined in 615/664 patients. 107 pat...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
Conclusion: The common CTAC-NDB with the spatial resolution compensation would be available in multicenter clinically, because the findings of the statistical images in patients with MCI and dementias showed similar tendency.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
1658Purpose: Although beneficial effects of acetyl-L-carnitine (ALC) in Alzheimer's disease (AD) have been reported, underlying neural correlates remain unclear. The current study aimed to investigate cerebral perfusion changes after ALC treatment in AD patients using technetium-99m hexamethylpropylene amine oxime single photon emission computed tomography (SPECT) METHOD AND MATERIALS: A total of 18 patients with early AD were recruited and assessed with brain SPECT, Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), Global Deterioration Scale (GDS), and Neuropsychiatric Inventory (NPI). Changes in brain...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
Conclusions: Dystonia and apraxia of speech were most closely related to a non-AD and myoclonus to an AD functional pattern of CBS. Individuals with an AD pattern presented with lower ACE-R and MMSE and higher HY scale scores. Functional nuclear imaging shows a potential to predict the different CBS variants while depicting their specific functional patterns.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
359Objectives: We designed a multi-pinhole (MPH) collimator for clinical brain SPECT imaging, which could potentially be used with the recently reported Tau-SPECT tracers (H. Watanabe et al, 2016). In this design two identical MPH collimators replace the existing collimators on a general-purpose-dual-head SPECT system. The pinholes are arranged at different axial positions to improve sampling. In addition, the collimator on one head is rotated 180 degree (about the axis normal to the collimator plane) with respect to the other one to further increase the axial sampling. Method: We determined the geometry of the system (e.g...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: New System Designs and Emerging Technologies Source Type: research
Conclusions: We have successfully synthesized a library of GnRH-R antagonists and evaluated the binding affinity. Moreover, two highly promising SPECT radiotracers were radioiodinated with 123I by a modified CuAAC. The binding affinity, serum stability, metabolic profile and binding to rat brain GnRH-R makes these promising compounds highly suitable candidates for further evaluation into imaging studies. References. 1.Meethal, S.; Smith, M.; Bowen, R.; Atwood, C., The gonadotropin connection in Alzheimer’s disease. Endocr 2005, 26 (3), 317-325. 2.Webber, K. M.; Perry, G.; Smith, M. A.; Casadesus, G., The Contribution...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Probes for Neuroimaging II Source Type: research
In this study, we used PCA to identify a metabolic covariance pattern that predicts the conversion from MCI to AD (so-called AD conversion-related pattern, ADCRP), and investigated the prognostic value of the resulting pattern expression score (PES). Methods: FDG PET scans of 544 MCI patients obtained from the ADNI database (median follow-up based on the reversed Kaplan-Meier method: 48 months [95 % CI: 47 - 48 months]) were studied. We implemented voxel-based PCA (Spetsieris, 2015) and standard SPM (as reference) analyses to disclose cerebral metabolic patterns associated with conversion from MCI to AD in a training datas...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Imaging Tau and Other Dementia Targets Source Type: research
Conclusions: These results are consistent with the hypothesis that microglial cells bearing CD206 trap fluorescent-labeled Tc-99m-tilmanocept in regions of BBB disruption. This provides the motivation for a clinical trial of intra-venously administered Tc-99m-tilmanocept with the goal of developing a SPECT/CT protocol for the detection of neuro-inflammation.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science II Source Type: research
In this study, we investigated whole brain functional connectivity changes of PCC using resting-state functional magnetic resonance imaging. Voxel-based functional connectivity with PCC was analyzed in OT-poor or OT-good AD patients, classified accor ding to the mean OT scores of the Mini-Mental State Examination subscale. The connectivities of dorsal frontal lobe, and lateral parietal and lateral temporal lobes with PCC in the right hemisphere were reduced in the OT-poor AD group compared with the OT-good AD group. A subtraction connectivity ma p of OT score differences (OT-good minus OT-poor) revealed the right middle te...
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
This study included 120 patients referred to a university memory clinic assessed using HMPAo SPECT, MRI, and CSF biomarkers. Three biomarker signatures suggestive of AD were analyzed (1, Aß1-42; 2, Aß1-42+t-tau and/or p-tau; 3, Aß1-42/p-tau). The clinical diagnoses were possible AD (n=29) or other causes of cognitive impairment (n=91). All CSF AD signatures were significantly (1, P=0.004; 2, P=0.017; 3, P=0.024) associated with the difference between inferior parietal perfusion and lateral dorsal frontal cortex perfusion. The hypoperfusion pattern discriminated between patients with positive CSF AD biomar...
Source: Alzheimer Disease and Associated Disorders - Category: Geriatrics Tags: Original Articles Source Type: research
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